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Cytochrome P450 Family 7

A cytochrome P450 enzyme family whose members function as steroid 7-alpha hydroxylases.

Also Known As:

CYP7 Enzymes; CYP7 Family

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hauser, Stefan: 2 articles (01/2016 - 01/2016)
2.	Höflinger, Philip: 2 articles (01/2016 - 01/2016)
3.	Schöls, Ludger: 2 articles (01/2016 - 01/2016)
4.	Theurer, Yvonne: 2 articles (01/2016 - 01/2016)
5.	Huang, Jianbo: 1 article (01/2021)
6.	Jiang, Jiarui: 1 article (01/2021)
7.	Jiang, Tao: 1 article (01/2021)
8.	Liu, Huifang: 1 article (01/2021)
9.	Liu, Muyi: 1 article (01/2021)
10.	Lou, Zhaohuan: 1 article (01/2021)

Related Diseases

1.	Hereditary Spastic Paraplegia 01/01/2016 - "Skin fibroblasts were obtained from a 47-year-old hereditary spastic paraplegia patient carrying a homozygous mutation Y275X in CYP7B1 (Cytochrome P450, Family 7, Subfamily B, Polypeptide 1), responsible for causing hereditary spastic paraplegia type 5 (SPG5). " 01/01/2016 - "Skin fibroblasts were obtained from a 47-year-old hereditary spastic paraplegia patient carrying a homozygous mutation R486C in CYP7B1 (Cytochrome P450, Family 7, Subfamily B, Polypeptide 1), responsible for causing hereditary spastic paraplegia type 5 (SPG5). "
2.	Atherosclerosis 01/01/2020 - "Peretinoin suppressed human cardiovascular cell calcification without inducing either secretion of APOC3 (apolipoprotein-CIII), which promotes atherogenesis, or reducing CYP7A1 (cytochrome P450 family 7 subfamily A member 1) expression, which occurred with cyclic retinoids all-trans RA, 9-cis RA, and 13-cis RA. "
3.	Inflammation (Inflammations) 12/01/2023 - "However, 25HC can also amplify inflammation and be converted by CYP7B1 (cytochrome P450 family 7 subfamily B member 1) to 7α,25-dihydroxycholesterol, a lipid with chemoattractant activity, via the G protein-coupled receptor EBI2 (Epstein-Barr virus-induced gene 2)/GPR183 (G protein-coupled receptor 183). "
4.	Hyperlipidemias (Hyperlipidemia) 01/01/2021 - "In addition, LREE can increase bile acid reabsorption and promote fecal excretion through farnesoid X receptor (FXR), apical sodium-dependent bile acid transporter (ASBT), organic solute transporter alpha (OST-α), and cytochrome P450 family 7 Subfamily A Member 1 (CYP7A1) thus restoring abnormal bile acid metabolism caused by hyperlipidemia."
5.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 11/29/2019 - "The genes STAP1 (signal transducing adaptor family member 1), CYP7A1 (cytochrome P450 family 7 subfamily A member 1), LIPA (lipase A, lysosomal acid type), ABCG5 (ATP binding cassette subfamily G member 5), ABCG8 (ATP binding cassette subfamily G member 8), and PNPLA5 (patatin like phospholipase domain containing 5), which can cause aberrations of lipid metabolism, are being evaluated as new targets for the diagnosis and personalized management of familial hypercholesterolemia."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Bile Acids and Salts (Bile Acids)
3.	Apolipoprotein C-III
4.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
5.	Retinoids
6.	Phospholipases (Phospholipase)
7.	Lipids
8.	Lipase (Acid Lipase)
9.	Enzymes
10.	Chemotactic Factors