NIMA-Interacting Peptidylprolyl Isomerase

A highly-conserved peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated SERINE- or THREONINE-PROLINE (pSer/Thr-Pro) motifs and causes conformational changes in certain proteins associated with the CELL CYCLE. It displays a preference for an acidic residue N-terminal to the isomerized proline bond and regulates MITOSIS, possibly by attenuating the mitosis-promoting activity of NIMA-RELATED KINASE 1.

Also Known As:

Networked: 42 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lu, Kun Ping: 5 articles (01/2019 - 04/2007)
2.	Lee, Tae Ho: 3 articles (01/2020 - 06/2011)
3.	Zhou, Xiao Zhen: 3 articles (01/2019 - 07/2013)
4.	Asano, Tomoichiro: 2 articles (01/2021 - 12/2012)
5.	Fujishiro, Midori: 2 articles (01/2021 - 12/2012)
6.	Kushiyama, Akifumi: 2 articles (01/2021 - 12/2012)
7.	Nakatsu, Yusuke: 2 articles (01/2021 - 12/2012)
8.	Sakoda, Hideyuki: 2 articles (01/2021 - 12/2012)
9.	Wang, Long: 2 articles (01/2020 - 01/2019)
10.	Liu, Hekun: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 07/02/2009 - "In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). " 09/01/2023 - "Peptidyl-prolyl cis/trans isomerase Pin1 has been proven to be closely associated with tumor progression. " 01/04/2019 - "Peptidyl-prolyl cis-trans isomerase Pin1 plays a crucial role in the development of human cancers. " 02/01/2011 - "The peptidylprolyl isomerase Pin1 is over-expressed in some human diseases including malignancies and chronic inflammatory diseases, this suggests that it contributes to the constitutive activation of certain intracellular signaling pathways that promote cell proliferation and cell invasion. " 04/01/2007 - "Pin1 protein was shown to be overexpressed in NSCLC tumor samples, and correlated with lymph node positive disease and tumor stage. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Exposure of MCF-7 and SK-BR-3 human breast cancer cells to WA resulted in downregulation of Pin1 protein. " 07/01/2013 - "Moreover, SENP1 also increases Pin1 protein stability in cell cultures, and Pin1 levels are positively correlated with SENP1 levels in human breast cancer specimens. " 01/01/2018 - "Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells." 02/01/2014 - "Overall, our current study suggests the potential of decursin as an attractive cancer therapeutic agent for breast cancer by targeting Pin1 protein." 01/01/2017 - "Mammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl cis/trans isomerase PIN1 at their centerpiece, in virtue of the ability of this unique enzyme to fine-tune the dynamic crosstalk between multiple molecular pathways. "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2006 - "The expression of Pin1 protein was increased progressively along with the disease process from normal cervix to CIN and to cervical cancer (P < 0.05). " 01/01/2018 - "In this study, we examined PIN1 protein expression by immunohistochemistry in 221 paraffin-embedded samples from cervical cancer patients, cervical intraepithelial neoplasia patients, and control tissues, and found that high expression of PIN1 was significantly associated with lymph node metastasis (P=0.002), advanced stage according to the International Federation of Gynecology and Obstetrics guidelines (P=0.026). "
4.	Lymphatic Metastasis 01/01/2018 - "In this study, we examined PIN1 protein expression by immunohistochemistry in 221 paraffin-embedded samples from cervical cancer patients, cervical intraepithelial neoplasia patients, and control tissues, and found that high expression of PIN1 was significantly associated with lymph node metastasis (P=0.002), advanced stage according to the International Federation of Gynecology and Obstetrics guidelines (P=0.026). "
5.	Infections 01/01/2020 - "In this study, the role of the cellular peptidyl-prolyl cis/trans isomerase Pin1 during HCMV infection was investigated. "

Related Drugs and Biologics

1.	Peptidylprolyl Isomerase (Prolyl Isomerase)
2.	Paraffin
3.	Dextrans (Dextran)
4.	decursin
5.	sodium sulfate (sodium bisulfate)
6.	Proteins (Proteins, Gene)
7.	tau Proteins (tau Protein)
8.	Messenger RNA (mRNA)
9.	Enzymes
10.	Inhibitor of Apoptosis Proteins

Related Therapies and Procedures

1.	Therapeutics