Connexin 26

A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.

Also Known As:

Connexin Cx26; Connexin beta-2; Gap Junction beta-2 protein; beta2 Connexin; 26, Connexin; Connexin beta 2; Connexin, beta2; Cx26, Connexin; Gap Junction beta 2 protein; beta-2, Connexin

Networked: 550 relevant articles (5 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Connexins: 2085
        Connexin 26: 550
        human GJB2 protein
        mouse Gjb2 protein
        rat Gjb2 protein
        Xenopus GJB2 protein

Experts

1.	Ikeda, Katsuhisa: 9 articles (01/2021 - 04/2002)
2.	Van Camp, Guy: 9 articles (10/2018 - 04/2003)
3.	Frei, Klemens: 9 articles (01/2017 - 07/2002)
4.	Lucas, Trevor: 9 articles (01/2017 - 07/2002)
5.	Mammano, Fabio: 8 articles (01/2022 - 01/2005)
6.	Ramsebner, Reinhard: 8 articles (01/2015 - 07/2002)
7.	Avraham, Karen B: 8 articles (09/2014 - 03/2002)
8.	Smith, Richard J H: 8 articles (08/2012 - 08/2002)
9.	Kamiya, Kazusaku: 7 articles (01/2021 - 02/2011)
10.	Baumgartner, Wolf-Dieter: 7 articles (06/2013 - 07/2002)

Related Diseases

1.	Hearing Loss (Hearing Impairment) 03/01/2014 - "ACEMg supplementation ameliorates progressive Connexin 26 hearing loss in a child." 01/01/2023 - "The objectives of this study were to describe trends in single-gene GJB2/6 (connexin 26/30) and multigene hearing loss panel (HLP) testing for hereditary hearing loss using real-world evidence. " 01/01/2018 - "Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common causes of hereditary hearing loss in humans, and previous studies showed postnatal development arrest of the organ of Corti in different Cx26-null mouse models. " 01/01/2014 - "To study connexin 26 (Cx26) gene mutations among autosomal recessive non-syndromal hearing loss in Kuwaiti patients and evaluate their effect on phenotypes. " 09/01/2010 - "In a recent study, the authors have shown that a heterozygous missense mutation, p.R184Q, in the connexin 26 (Cx26) is causally related to hearing loss. "
2.	Deafness (Deaf Mutism) 11/01/2007 - "Mutations in the connexin 26 gene seem to be extremely common in non-syndromic hereditary deafness genesis, especially the 35delG, but there are still only a few studies that describe the audiometric characteristics of patients with these mutations. " 12/01/2005 - "Previous studies have shown that one of these genes, connexin 26 (GJB2), accounts for 30-60% of such deafness, but the relative contribution of the many other genes is not known, especially in the outbred UK population. " 09/01/2003 - "After taking into account other factors which are known to affect language development and speech perception in children with impaired hearing, no significant differences were found between the 15 children where connexin 26 was known to be the cause of deafness and the other 37 children in the study." 10/01/2001 - "[Study of a mutation in connexin 26 gene associated with congenital sensorineural deafness]." 11/01/1997 - "Two different connexin 26 mutations in an inbred kindred segregating non-syndromic recessive deafness: implications for genetic studies in isolated populations."
3.	Neoplasms (Cancer) 10/01/2001 - "In the present study, we have evaluated the efficacy of the HSV-tk/GCV treatment in a panel of pancreatic tumor cells (NP-9, NP-18, NP-31) and the potentiation of the cytotoxic effect in combination with the overexpression of the connexin 26 gene (Cx26). " 01/01/2014 - "In contrast, enhanced GJC communication through the overexpression of wild-type connexin Cx26 increased tumor incidence. " 05/01/2010 - "Connexin 26 (Cx26), one of the gap junction-forming family members, is more controversial than other members, as a tumor suppressor. " 02/01/2008 - "Connexin 26 (Cx26) is one of the gap junction-forming family members classically considered to be tumor suppressors. " 11/01/2006 - "Connexin 26 may have a role as a tumor suppressor in SCCHN. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2006 - "Advanced cells within PC-3 and LNCaP prostate cancer progression models exhibit elevated connexin 26 (Cx26) levels-a trend validated in clinical samples. " 02/01/2004 - "Connexin 26 induces growth suppression, apoptosis and increased efficacy of doxorubicin in prostate cancer cells."
5.	Nonsyndromic Deafness 06/01/2022 - "Analysis of Genetic Variations in Connexin 26 ( GJB2 ) Gene among Nonsyndromic Hearing Impairment: Familial Study." 04/01/2008 - "This study aimed to assess mutations in GJB2 gene (connexin 26), as well as A1555G mitochondrial mutation in both the patients with profound genetic nonsyndromic hearing loss and healthy controls. " 06/01/2004 - "A study of patients with nonsyndromic hearing loss seen over a period of 2 years who had connexin 26 mutation testing. " 06/01/2001 - "To study the relation between nonsyndromic hearing loss in Chinese and mutations in connexin 26 (Cx 26) gene and to explore the pathogenic mechanism. " 06/01/2001 - "[Study on mutations in the connexin 26 gene among Chinese with nonsyndromic hearing loss]."

Related Drugs and Biologics

1.	Connexin 26
2.	12S ribosomal RNA
3.	Adenosine Triphosphatases (ATPase)
4.	Aminoglycosides
5.	Sodium-Potassium-Chloride Symporters
6.	Doxorubicin (Adriamycin)
7.	Connexin 30
8.	Connexins
9.	Proteins (Proteins, Gene)
10.	Connexin 43 (Connexin43)

Related Therapies and Procedures

1.	Cochlear Implants (Cochlear Implant)
2.	Therapeutics
3.	Hearing Aids (Hearing Aid)
4.	Gastrectomy
5.	Cochlear Implantation