Patched Receptors

A family of 12-pass transmembrane proteins originally identified in Drosophila that are receptors for HEDGEHOG PROTEINS. They have important roles in regulating CELL PROLIFERATION; CELL DIFFERENTIAION; and BODY PATTERNING and may also function as TUMOR SUPPRESSOR PROTEINS.

Also Known As:

Networked: 58 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Mus-Veteau, Isabelle: 7 articles (05/2022 - 09/2009)
2.	Ruat, Martial: 3 articles (01/2021 - 09/2009)
3.	Lee, Youngsoo: 3 articles (01/2015 - 07/2006)
4.	McKinnon, Peter J: 3 articles (01/2015 - 07/2006)
5.	Bidet, Michel: 3 articles (11/2012 - 09/2009)
6.	Mollat, Patrick: 3 articles (11/2012 - 09/2009)
7.	Hasanovic, Anida: 2 articles (05/2022 - 01/2018)
8.	Segal, Rosalind A: 2 articles (12/2018 - 11/2003)
9.	Lalli, Enzo: 2 articles (01/2018 - 09/2015)
10.	Peacock, C D: 2 articles (01/2017 - 09/2004)

Related Diseases

1.	Medulloblastoma 11/01/2003 - "Mutations of the Shh receptor PATCHED (PTCH) are associated with medulloblastomas, which have not been found to have loss of PTCH heterozygosity. " 05/01/2012 - "In this study, we describe the expression pattern of Shh, its receptor patched, smoothened, and its effectors that belong to the Gli family of transcription factors, during normal human cerebellum development from 10 weeks of gestational age, and in medulloblastomas that represents a case of abnormal cell proliferation in the cerebellum. " 01/01/2015 - "To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic Hedgehog receptor, Patched 1. We found that conditional loss of Dicer in mouse neural progenitors induced massive Trp53-independent apoptosis in all proliferative zones of the brain and decreased proliferation of cerebellar granule progenitors at embryonic day 15.5 leading to abnormal cerebellar development and perinatal lethality. " 06/13/2014 - "To assess their role in cerebellar and medulloblastoma (MB) development, we deleted the miR-17∼92 cluster family in Nestin-positive neural progenitors and in mice heterozygous for the Sonic Hedgehog (SHH) receptor Patched 1 (Ptch1(+/-)). " 01/01/2017 - "Deletions in the receptor Patched (PTCH) or activating mutations in Smoothened (SMO) have been reported in basal cell carcinoma and medulloblastoma, but are largely absent in most tumor types. "
2.	Polyps 08/01/2004 - "In this study, normal colon and colonic lesions (hyperplastic polyp, adenoma, and colonic adenocarcinoma) were examined by immunohistochemistry using antibodies against Hh signalling molecules: the secreted protein Sonic hedgehog (SHH), its receptor Patched (PTCH), and the PTCH-associated transmembrane protein Smoothened (SMOH). "
3.	Adenoma (Adenomas) 08/01/2004 - "In this study, normal colon and colonic lesions (hyperplastic polyp, adenoma, and colonic adenocarcinoma) were examined by immunohistochemistry using antibodies against Hh signalling molecules: the secreted protein Sonic hedgehog (SHH), its receptor Patched (PTCH), and the PTCH-associated transmembrane protein Smoothened (SMOH). "
4.	Adenocarcinoma 08/01/2004 - "In this study, normal colon and colonic lesions (hyperplastic polyp, adenoma, and colonic adenocarcinoma) were examined by immunohistochemistry using antibodies against Hh signalling molecules: the secreted protein Sonic hedgehog (SHH), its receptor Patched (PTCH), and the PTCH-associated transmembrane protein Smoothened (SMOH). "
5.	Neoplasms (Cancer) 05/05/2022 - "The Hedgehog receptor Patched (Ptch1) is overexpressed in many types of cancers. " 05/05/2022 - "Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched." 04/23/2019 - "Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc). " 11/01/2012 - "The Hedgehog receptor Patched (Ptc) is a Hedgehog signaling target gene that is overexpressed in many cancer cells. " 03/01/2012 - "Activation of the hedgehog signal transduction pathway, triggered by hedgehog binding to the transmembrane receptor patched 1 (PTCH1) or by mutations in the PTCH1 gene, plays an important role in the development of various tumors. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	Antibodies
4.	Ligands
5.	Smoothened Receptor
6.	Nestin
7.	Messenger RNA (mRNA)
8.	Peptides (Polypeptides)
9.	Brain-Derived Neurotrophic Factor (BDNF)
10.	Keratins (Keratin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Aftercare (After-Treatment)