PAX3 Transcription Factor

A paired box transcription factor that functions in CELL PROLIFERATION; CELL MIGRATION; and APOPTOSIS. It also is involved in MYOGENESIS and neural development. Mutations in the PAX3 gene are associated with WAARDENBURG SYNDROME TYPE 1.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Schäfer, Beat W: 2 articles (01/2015 - 05/2008)
2.	Wachtel, Marco: 2 articles (01/2015 - 05/2008)
3.	Corry, Gareth N: 2 articles (09/2010 - 06/2008)
4.	Hendzel, Michael J: 2 articles (09/2010 - 06/2008)
5.	Underhill, D Alan: 2 articles (09/2010 - 06/2008)
6.	Schäfer, B W: 2 articles (11/2007 - 02/2001)
7.	Celis, Esteban: 2 articles (07/2006 - 06/2005)
8.	Nuss, Rebecca A: 2 articles (07/2006 - 06/2005)
9.	Rodeberg, David A: 2 articles (07/2006 - 06/2005)
10.	He, Wei: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2009 - "The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key component in alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. " 11/08/2007 - "The chromosomal translocation t(2;13), characteristic for the aggressive childhood cancer alveolar rhabdomyosarcoma (aRMS), generates the chimeric transcription factor PAX3/FKHR with a well known oncogenic role. " 02/01/2001 - "Deregulated expression of the transcription factor PAX3 was observed previously in several tumors like rhabdomyosarcoma and Ewing's sarcoma. " 12/22/2007 - "Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis. " 07/01/2006 - "The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. "
2.	Melanoma (Melanoma, Malignant) 09/01/2015 - "Compared with normal human skin tissue and human or mouse melanocytes, the abundance of Cdh1 was decreased and that of the transcription factor PAX3 was increased in human melanoma tissue and human or mouse melanoma cell lines, respectively; Cdh1 abundance was further decreased with advanced stages of human melanoma. " 08/12/2011 - "The PAX3 transcription factor is the key regulator of melanocyte development during embryogenesis and is also frequently found in melanoma cells. " 12/22/2007 - "Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis. " 07/01/2006 - "The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. "
3.	Alveolar Rhabdomyosarcoma 01/01/2015 - "In particular, outcomes remain dismal for patients with metastatic alveolar rhabdomyosarcoma (aRMS), where the chimeric transcription factor PAX3/7-FOXO1 has been implicated but problematic to target. " 05/15/2008 - "One example of this is alveolar rhabdomyosarcoma (aRMS), in which specific translocations lead to the formation of the chimeric transcription factor PAX3/FKHR. " 06/01/2005 - "Alveolar rhabdomyosarcoma (ARMS) frequently contains the fusion transcription factor PAX3/FKHR. " 12/15/2009 - "The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key component in alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. " 11/08/2007 - "The chromosomal translocation t(2;13), characteristic for the aggressive childhood cancer alveolar rhabdomyosarcoma (aRMS), generates the chimeric transcription factor PAX3/FKHR with a well known oncogenic role. "
4.	Waardenburg Syndrome (Klein Syndrome) 09/10/2010 - "The transcription factor PAX3 is essential for myogenesis and neural crest development, and is one of several genes mutated in human Waardenburg syndrome. " 06/15/2008 - "Mutations in the transcription factor PAX3 cause Waardenburg syndrome (WS) in humans and the mouse Splotch mutant, which display similar neural crest-derived defects. "
5.	Ewing Sarcoma (Sarcoma, Ewing) 02/01/2001 - "Deregulated expression of the transcription factor PAX3 was observed previously in several tumors like rhabdomyosarcoma and Ewing's sarcoma. " 07/01/2006 - "The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. "

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