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Sorbitol (Yal)

A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

Also Known As:

Yal; Medevac; Glucitol; Baxter Brand of Sorbitol; Medefield Brand of Sorbitol; Pfizer Brand of Sorbitol; Sorbilax; Trommsdorff Brand of Sorbitol; klysma Sorbit; Sorbitol Pfizer Brand; D-Glucitol

Networked: 892 relevant articles (38 outcomes, 66 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Experts

1.	Kador, Peter F: 4 articles (08/2012 - 04/2003)
2.	Blessing, Karen: 3 articles (08/2012 - 05/2010)
3.	Obrosova, Irina G: 3 articles (07/2011 - 01/2002)
4.	Karch, Helge: 3 articles (07/2007 - 09/2002)
5.	Goodman, Gens P: 2 articles (09/2012 - 07/2010)
6.	Belmont, Philip J: 2 articles (09/2012 - 07/2010)
7.	Zhang, Peng: 2 articles (08/2012 - 01/2011)
8.	Randazzo, James: 2 articles (08/2012 - 01/2011)
9.	Lou, Marjorie F: 2 articles (08/2012 - 04/2003)
10.	Galan, Henry L: 2 articles (03/2012 - 08/2010)

Related Diseases

1.	Hepatic Encephalopathy 08/01/2002 - "Hepatic plasma flow was estimated in patients with acute liver failure after development of hepatic encephalopathy grade III, by the use of liver vein catheterization and continuous infusion of sorbitol. " 06/01/1981 - "Sorbitol solution has been used to a control substance of evaluating the efficacy of lactulose therapy for hepatic encephalopathy (HE). " 03/01/1998 - "Hepatic plasma flow estimated according to Fick's principle in patients with hepatic encephalopathy: evaluation of indocyanine green and D-sorbitol as test substances." 09/01/1984 - "Portal systemic encephalopathy-sorbitol--a potential replacement for lactulose." 05/01/1983 - "These findings indicate that both sorbitol and lactulose are extensively fermented by the colonic flora and that the possibility of replacing lactulose with the much cheaper sorbitol in the treatment of portal-systemic encephalopathy ought to be investigated. " Order ALL the reference details at left...
2.	Hyperglycemia 11/01/2007 - "Thus we hypothesized that elevated level of sorbitol contributes to the development of hyperglycemia-induced dysfunction of microvessels. " 02/01/2003 - "Sorbitol levels in aortic endothelial cells and within the smooth muscle layer were significantly increased with hyperglycemia. " 02/01/2002 - "The process of sorbitol accumulation is more evident than glycation in the initial stage of hyperglycemia. " 05/01/1996 - "Stepwise regression analysis highlighted the fact that the hyperglycemia-dependent increase in RBC sorbitol was significantly influenced by GSH concentrations (partial F = 14.6, P < .001). " 07/01/1989 - "It is unclear by which mechanism hyperglycemia is altering the metabolism and functions of vascular cells, although changes in nonenzymatic protein glycosylation and increases in cellular sorbitol levels have been postulated to be involved. " Order ALL the reference details at left...
3.	Fibrosis (Cirrhosis) 03/15/2004 - "The functional hepatic flow (FHF) and total hepatic flow (THF) were determined by means of modified hepatic clearance of D-sorbitol combined with duplex doppler color sonography in 20 patients with cirrhosis and 10 healthy volunteers. " 03/15/2004 - "D-sorbitol total clearance was significantly reduced in cirrhosis compared to control (P<0.01), while D-sorbitol renal clearance was significantly increased in cirrhosis (P<0.05). " 03/15/2004 - "FHF, evaluated by means of the D-sorbitol clearance, was significantly reduced in patients with cirrhosis in comparison to controls (764.74+/-167.91 vs 1195.04+/-242.97 mL/min, P<0.01). " 04/01/1989 - "Sorbitol clearance: shift from flow-limitation in controls to enzyme-flow dependence in cirrhosis." 10/01/1987 - "Ten normal subjects, 10 patients with cirrhosis and 12 cirrhotics with surgical portacaval shunts were studied after oral and intravenous administration of a 2 g dose of sorbitol. " Order ALL the reference details at left...
4.	Cataract (Cataracts) 01/01/2001 - "Sorbitol-lowering drugs were the first to be examined systematically and progressed to clinical trials which were disappointing, and now the entire rationale for their use in prevention of cataract is questionable. " 01/01/2012 - "Activation of the sorbitol pathway indeed enhances the risk of cataract development in conditions such as metabolic syndrome. " 01/01/2012 - "Either way, an elevated sorbitol pathway seemed to be the predisposing factor responsible for cataract formation in these mutant rats. " 01/01/2012 - "Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats." 01/01/2011 - "However, compared to untreated rats, compounds 4 and 8 delayed vacuole formation by 20 days and 12 days, respectively, and cortical cataract formation by 8 and 3 days, respectively, without reducing lenticular sorbitol. " Order ALL the reference details at left...
5.	Diabetic Neuropathies (Diabetic Neuropathy) 01/01/2002 - "However, some experimental intervention studies and clinical trials of ARIs on diabetic neuropathy appeared disappointing because of either 1) their inadequate design and, in particular, insufficient correction of the sorbitol pathway activity or 2) the inability to reverse established functional and metabolic deficits of diabetic neuropathy by AR inhibition in general. " 05/15/2009 - "HPLC with pulsed amperometric detection for sorbitol as a biomarker for diabetic neuropathy." 03/01/2002 - "Sorbitol accumulation in nerves has been regarded as one of the major causes of diabetic neuropathy. " 01/01/2002 - "In conclusion, treatment with adequate doses of ARIs (that is, doses that completely inhibit increased sorbitol pathway activity) is an effective approach for reversal of, at least, early diabetic neuropathy." 01/01/1998 - "The abnormal activation of sorbitol tract is very significant agent of development of diabetic neuropathy. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Lactulose (Duphalac)
2.	Glucose (Dextrose)
3.	Xylitol
4.	Aldehyde Reductase (Aldose Reductase)
5.	Galactose (Galactopyranose)
6.	Chewing Gum (Chewing Gums)
7.	lactitol
8.	Mannitol (Osmitrol)
9.	sorbinil
10.	ONO 2235 (epalrestat)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Toothbrushing
3.	Dental Care
4.	Aftercare (After-Treatment)
5.	Parenteral Nutrition

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