Zinc Finger E-box-Binding Homeobox 1

A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.

Also Known As:

NIL-2-A Zinc Finger Protein; TCF8 Protein; Transcription Factor 8; Zeb1 Transcription Factor; NIL 2 A Zinc Finger Protein; Transcription Factor, Zeb1; Zinc Finger E box Binding Homeobox 1

Networked: 278 relevant articles (2 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brabletz, Thomas: 14 articles (01/2021 - 04/2007)
2.	Wang, Jing: 8 articles (02/2022 - 06/2012)
3.	Brabletz, Simone: 7 articles (01/2021 - 12/2009)
4.	Postigo, Antonio: 7 articles (01/2021 - 11/2011)
5.	Stemmler, Marc P: 7 articles (01/2021 - 12/2009)
6.	Aldave, Anthony J: 6 articles (11/2019 - 01/2012)
7.	Liu, Xin: 5 articles (11/2022 - 06/2014)
8.	Gibbons, Don L: 5 articles (04/2022 - 06/2014)
9.	Cuatrecasas, Miriam: 5 articles (01/2021 - 11/2011)
10.	Liu, Yongqing: 5 articles (01/2021 - 04/2013)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 10/06/2023 - "Ultimately, zinc finger E-box binding homeobox 1 (ZEB1) was identified as the upstream transcriptional factor responsible for BCAT2 up-regulation in melanoma. " 01/01/2022 - "ZEB1 transcription factor promotes immune escape in melanoma." 01/01/2021 - "miR-34a overexpression inhibited expression and activity of the transcription factor ZEB1, resulting in decreased proliferation and migration of melanoma cells. " 01/01/2019 - "In addition, a positive correlation between ZEB1-AS1 and ZEB1 (zinc finger E-box binding homeobox 1) gene expression was verified in primary and metastatic melanomas. " 10/17/2018 - "Moreover, zinc-finger E-box-binding homeobox 1 (ZEB1) was identified as a direct target gene of miR-342 in melanoma. "
2.	Pre-Eclampsia (Preeclampsia) 01/01/2023 - "Insulin-like growth factor 1 ameliorates pre-eclampsia by inhibiting zinc finger E-box binding homeobox 1 by up-regulation of microRNA-183."
3.	Neoplasms (Cancer) 07/01/2020 - "In order to elucidate this behavior, our study aimed to investigate the immunoexpression in such tumors of the most important transcriptional factors [Twist, Snail, Slug, and zinc finger E-box binding homeobox 1 (ZEB1)] involved in the epithelial-mesenchymal transition process. " 09/01/2018 - "Studies have reported that Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is overexpressed in many malignant tumors. " 10/01/2017 - "Several previous studies have revealed that the expression of zinc finger E-box binding homeobox 1 (ZEB1) in solid malignancies has an important significance on the clinical outcome of patients. " 11/01/2023 - "In the current review, we will broadly describe how ZEB1, or Zinc-finger E-box Binding Homeobox 1, reinforces immune exhaustion in cancer or contributes to loss of self-tolerance in auto-immune conditions. " 01/01/2023 - "In in vitro cancer cell lines and an in vivo spontaneous HCC mouse model, DIO3OS markedly represses tumor development via its suppressive role in CSCs through downregulation of zinc finger E-box binding homeobox 1 (ZEB1). "
4.	Neoplasm Metastasis (Metastasis) 01/01/2018 - "Here, we address whether ceRNAs govern metastasis driven by the EMT-activating transcription factor ZEB1. " 06/01/2017 - "Moreover, SNHG1 affected the expression of zinc finger E-box binding homeobox 1(ZEB1), which has also been observed to be up-regulated in SCC and to promote cell metastasis and invasion. " 09/01/2016 - "Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition." 03/01/2015 - "Zinc-finger E-box binding homeobox 1 (ZEB1) is an important regulator of epithelial-to-mesenchymal transition and is associated with various types of metastasis. " 07/01/2014 - "Experimental evidence has suggested a role for the transcriptional repressor Zinc finger E-box binding homeobox 1 (ZEB1) in epithelial-mesenchymal transition, invasion, and metastasis in PDAC. "
5.	Breast Neoplasms (Breast Cancer) 07/01/2021 - "Prior studies have noted that zinc finger E-box binding homeobox 1 (ZEB1) is a master transcription regulator, affecting the expression of nearly 2000 genes in breast cancer cells, especially in the epithelial-mesenchymal transition (EMT) process. " 01/01/2020 - "Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer." 08/21/2015 - "Herein we showed by analyzing publicly available expression data from 1488 human primary breast tumors that the gene encoding the transcription factor ZEB1 was the most correlated with LPAR1 encoding LPA1. " 01/01/2022 - "Micro ribonucleic acid-448 regulates zinc finger e-box binding homeobox 1 to inhibit the growth of breast cancer cells and increase their sensitivity to chemotherapy." 01/01/2020 - "Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer."

Related Drugs and Biologics

1.	Insulin-Like Peptides
2.	Cadherins (E-Cadherin)
3.	Transcription Factors (Transcription Factor)
4.	Proteins (Proteins, Gene)
5.	Long Noncoding RNA
6.	Transforming Growth Factors (Transforming Growth Factor)
7.	Vimentin
8.	Catenins
9.	Messenger RNA (mRNA)
10.	MicroRNAs (MicroRNA)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Radiotherapy
5.	Castration