One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.
Also Known As:
AcPase V; Acid Phosphatase V; TRAP Type 5 AcPase; TRAcP; Tartrate-Resistant Acid Phosphatase Type 5; Type 5 Acid Phosphatase; Uteroferrin; Acid Phosphatase, Tartrate-Resistant; Phosphatase V, Acid; Phosphatase, Tartrate-Resistant Acid; Tartrate Resistant Acid Phosphatase; Tartrate Resistant Acid Phosphatase Type 5; V, AcPase; V, Acid Phosphatase