Notch3 Receptor

A notch receptor characterized by a large extracellular domain containing 34 EPIDERMAL GROWTH FACTOR-like repeats. It functions to regulate CELL DIFFERENTIATION; APOPTOSIS; and CELL PROLIFERATION. Mutations in the EGF repeats of Notch-3 are associated with CADASIL.

Also Known As:

Networked: 115 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Joutel, Anne: 11 articles (01/2018 - 01/2003)
2.	Lee, Soo Jung: 6 articles (01/2022 - 01/2012)
3.	Lesnik Oberstein, Saskia A J: 6 articles (01/2022 - 06/2014)
4.	Rutten, Julie W: 6 articles (01/2022 - 06/2014)
5.	Wang, Michael M: 6 articles (01/2022 - 01/2012)
6.	Zhang, Xiaojie: 6 articles (01/2022 - 01/2012)
7.	Domenga-Denier, Valérie: 6 articles (01/2018 - 06/2013)
8.	Cognat, Emmanuel: 5 articles (02/2015 - 06/2013)
9.	Kalimo, Hannu: 5 articles (09/2014 - 07/2002)
10.	Chabriat, Hugues: 4 articles (01/2019 - 02/2007)

Related Diseases

1.	CADASIL 01/01/2020 - "Our study here identified G73A as a new mutation in NOTCH3 to cause CADASIL and revealed that the G73A mutation and two known mutants R75P and R133C decreased NOTCH3 protein turnover and induced cell death." 01/01/2019 - "Herein, an attempt is made to shed light on the actual molecular mechanism underlying CADASIL syndrome, through insights extracted from comprehensive evolutionary studies and in silico modelling on Notch 3 protein. " 01/01/2014 - "Herein, we attempt to shed light to the actual molecular mechanism underlying CADASIL via insights that we have from preliminary in silico and proteomics studies on the Notch3 protein. " 10/01/2023 - "CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral arteriopathy caused by a neurogenic locus notch homolog protein 3 (NOTCH3) gene mutation. " 08/01/2023 - "Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common monogenic hereditary small cerebral vessel disease, which is caused by mutation of the neurogenic locus notch homolog protein 3 gene (NOTCH3). "
2.	Neoplasms (Cancer) 01/01/2021 - "Multifaceted targeting strategies in cancer against the human notch 3 protein: a computational study." 03/01/2013 - "Previous studies have demonstrated that the Notch3 receptor is involved in the pathogenesis of various types of malignancies, including human NFPAs. " 01/01/2021 - "Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. " 10/25/2016 - "We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt. " 05/24/2016 - "Furthermore, results from Notch3 silencing and N3ICD overexpression demonstrated that NAC prevented malignant phenotypes through down-regulation of Notch3 protein in multiple cancer cells. "
3.	Pituitary Neoplasms (Pituitary Adenoma) 03/01/2013 - "The current study focused on the expression of the Notch3 receptor and its ligand Jagged1 in three types of pituitary adenomas and in the normal pituitary gland. " 03/01/2013 - "Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas." 01/01/2012 - "We found, using reverse transcriptase-polymerase chain reaction, that Notch3 mRNA was significantly upregulated in clinically non-functioning pituitary adenomas, and, using Western blotting, that Notch3 protein was expressed at a higher level in non-functioning pituitary adenomas than in normal human pituitary tissue. " 03/01/2017 - "This study aimed to evaluate the distinct expression of TP63 isoforms (TAp63 and ΔNp63), as well as its correlation with Notch3 receptor and its ligand Jagged1 in human pituitary adenomas at the messenger RNA (mRNA) level. "
4.	Stroke (Strokes) 05/01/2014 - "In short-term studies, stroke outcome was worse in NOTCH3 null mice, consistent with the notion that the lack of the NOTCH3 receptor affects white matter stroke susceptibility." 11/29/2002 - "Mutations of the Notch-3 receptor result in an arteriopathy that predisposes to early-onset stroke. " 01/01/2012 - "Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective arterial smooth muscle degeneration. " 01/01/2017 - "CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. " 06/14/2002 - "Mutations in the Notch3 receptor result in the cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephelopathy (CADASIL) syndrome, a heritable arteriopathy predisposing to early onset stroke. "
5.	Lung Neoplasms (Lung Cancer) 01/15/2010 - "These findings rationalize a mechanistic approach to lung cancer treatment based on Notch3 receptor-targeted therapeutic development." 01/01/2021 - "Notch 3 has been shown to play a major role in lung cancer function and therefore, inhibition of notch 3 protein activation represents a clear plan for cancer treatment. " 02/20/2009 - "The purpose of this study is to explore the relationship between TSG101 protein and Notch3 receptor in human lung cancer. " 02/01/2013 - "Analysis of the expression of the Notch3 receptor protein in adult lung cancer." 02/20/2009 - "Down-regulation of TSG101 protein was correlated with the up- regulation of Notch 3 receptor in lung cancer."

Related Drugs and Biologics

1.	Ligands
2.	Protein Isoforms (Isoforms)
3.	Messenger RNA (mRNA)
4.	Transcription Factors (Transcription Factor)
5.	Peptides (Polypeptides)
6.	DNA (Deoxyribonucleic Acid)
7.	Jagged-1 Protein
8.	Tsg101 protein
9.	aspartyl-proline (Asp-Pro)
10.	Cysteine (L-Cysteine)