APOBEC Deaminases

A family of conserved cytidine deaminases that catalyze the DEAMINATION of CYTIDINE to URIDINE. They are characterized by N and C-terminal zinc-dependent catalytic domains and have important functions in RNA EDITING; EPIGENTIC PROCESSES; and the INNATE IMMUNE RESPONSE against viruses.

Also Known As:

Networked: 36 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Harris, Reuben S: 4 articles (01/2021 - 07/2015)
2.	Chen, Xiaojiang S: 2 articles (04/2022 - 12/2020)
3.	Martens, John W M: 2 articles (01/2022 - 05/2016)
4.	Shilov, E S: 2 articles (01/2022 - 01/2022)
5.	Shilova, O N: 2 articles (01/2022 - 01/2022)
6.	Tsyba, D L: 2 articles (01/2022 - 01/2022)
7.	Cho, Raymond J: 2 articles (04/2021 - 01/2018)
8.	South, Andrew P: 2 articles (04/2021 - 01/2018)
9.	den Breems, Nicoline Y: 2 articles (04/2021 - 01/2018)
10.	Cheng, Adam Z: 2 articles (01/2021 - 12/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC enzymes responsible. " 11/28/2022 - "Certain APOBEC enzymes can displace RPA, bind and scan ssDNA efficiently to search for cytosines, and can become highly overexpressed in tumor cells. " 04/30/2021 - "Based on comparative mutational signature analysis, we propose that the history of tobacco use and traumatic injury may have collaborated in activating APOBEC enzymes and the clock-like mutational process, ultimately leading to cancer formation. " 01/01/2021 - "Since the discovery of the role of the APOBEC enzymes in human cancers, the mechanisms of this type of mutagenesis remain little understood. " 10/01/2020 - "Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. "
2.	Carcinogenesis 11/25/2021 - "APOBEC enzymes are important players in immunity and may contribute to carcinogenesis. " 01/01/2020 - "HPV infections may initiate prostate oncogenesis directly and influence oncogenesis indirectly via APOBEC enzymes. " 01/01/2022 - "Mutagenic Activity of AID/APOBEC Deaminases in Antiviral Defense and Carcinogenesis." 01/01/2022 - "[Mutagenic Activity of AID/APOBEC Deaminases in Antiviral Defense and Carcinogenesis]." 01/10/2021 - "This study, from the perspective of HBV genomic epidemiology, systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides (APOBEC) family in the inflammation-to-cancer transformation. "
3.	Inflammation (Inflammations) 01/10/2021 - "This study, from the perspective of HBV genomic epidemiology, systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides (APOBEC) family in the inflammation-to-cancer transformation. "
4.	Infections 08/01/2020 - "The present study aimed to investigate whether apolipoprotein B mRNA-editing enzyme catalytic polypeptides (A3) are involved in the regulation of cervical cancer development and human papilloma virus (HPV)16 sustained infection in Uighur females. "
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 08/01/2020 - "The present study aimed to investigate whether apolipoprotein B mRNA-editing enzyme catalytic polypeptides (A3) are involved in the regulation of cervical cancer development and human papilloma virus (HPV)16 sustained infection in Uighur females. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Peptides (Polypeptides)
3.	APOBEC-1 Deaminase
4.	Apolipoproteins
5.	Antiviral Agents (Antivirals)
6.	Messenger RNA (mRNA)
7.	RNA (Ribonucleic Acid)
8.	Nucleotides
9.	Ligands
10.	Cytosine

Related Therapies and Procedures

1.	Therapeutics