Transcription Activator-Like Effectors

Virulence factors of pathogenic plant bacteria, such as XANTHOMONAS species, that bind to specific sequences in the PROMOTER REGIONS of host DNA to induce transcription of specific host genes. Variations in the DNA binding domain of TALE family members account for the variations in DNA specificity. The TALE DNA-binding domains are used in various GENETIC TECHNIQUES by fusing them with various DNA modifying enzymes to detect and manipulate sequence-specific targeted DNA sites.

Also Known As:

TAL Effectors; Activator-Like Effector, Transcription; Effector, TAL; Effector, Transcription Activator-Like; Effectors, TAL; Effectors, Transcription Activator-Like; Transcription Activator Like Effector; Transcription Activator Like Effectors; TAL Effector; Transcription Activator-Like Effector

Networked: 70 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Bing: 6 articles (11/2019 - 05/2013)
2.	Bogdanove, Adam J: 6 articles (01/2017 - 09/2012)
3.	White, Frank F: 5 articles (11/2019 - 01/2014)
4.	Tian, Dongsheng: 4 articles (01/2022 - 09/2015)
5.	Yin, Zhongchao: 4 articles (01/2022 - 09/2015)
6.	Frommer, Wolf B: 4 articles (11/2019 - 01/2014)
7.	Auguy, Florence: 3 articles (05/2022 - 01/2018)
8.	Cunnac, Sébastien: 3 articles (05/2022 - 01/2018)
9.	Szurek, Boris: 3 articles (05/2022 - 01/2018)
10.	Verdier, Valérie: 3 articles (05/2022 - 12/2012)

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary) 01/01/2021 - "Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a major translational hurdle. " 04/01/2023 - "Compared to its predecessors, zinc-finger nucleases (ZFN) and transcription activator-like effectors (TALEN), clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) is currently the most efficient molecular tool for genome editing. This system, originally identified as a bacterial adaptive immune system, is capable of cutting and modifying any gene of a large number of living organisms. Numerous trials using this technology are being developed to provide effective treatment for several diseases, such as cancer, cardiovascular and ophthalmic disorders. In research, this technology is increasingly used for genetic disease modelling, providing meaningful models of relevant studies as well as a better understanding of underlying pathological mechanisms. Many molecular tools are now available to put this technique into practice in laboratories, and despite the technical and ethical issues raised by manipulation of the genome, CRIPSR/Cas9 offers a new breath of hope for therapeutic research around the world."
2.	Infections 12/29/2021 - "The infection strategy of many Xanthomonas strains is based on transcription activator-like effectors (TALEs), which are secreted into the host cells and act as transcriptional activators of plant genes that are beneficial for the bacteria.The" 03/27/2023 - "Most plant-pathogenic Xanthomonas bacteria harbor transcription activator-like effector (TALE) genes, which function as transcriptional activators of host plant genes and support infection. " 12/20/2021 - "Xanthomonas oryzae delivers transcription activator-like effectors (TALEs) into plant cells to facilitate infection. " 01/01/2021 - "Transcription activator-like effectors (TALEs), which induce the expression of specific plant genes to promote infection, are the main pathogenic determinants of various Xanthomonas bacteria. " 12/01/2019 - "The targets of TAL and non-TAL effectors provide insight to the genes governing susceptibility and resistance during Xanthomonas infection. "
3.	Neoplasms (Cancer) 01/01/2015 - "Tadpoles and froglets derived from embryos injected with TAL effector nucleases targeting the apc gene rapidly developed intestinal hyperplasia and other neoplasms observed in FAP patients, including desmoid tumors and medulloblastomas. " 01/01/2021 - "These genome editing technologies (Zinc finger nucleases, TAL effector nucleases), specifically CRISPR-Cas system, revolutionized the field of genetic engineering and is widely applied to create cell and animal models for various hereditary, infectious human diseases and cancer, to analyze and understand the molecular and cellular base of pathogenesis, to find potential drug/treatment targets, to eliminate pathogenic DNA changes in various medical conditions and to create future "precise medication". " 01/01/2021 - "We provide insights into how cancer-related DNMT mutations alter de novo methylation in vivo, and demonstrate local and tuneable cytosine methylation by light-controlled DNMTs fused to a programmable transcription activator-like effector domain targeting pericentromeric satellite-3 DNA. " 04/01/2023 - "Compared to its predecessors, zinc-finger nucleases (ZFN) and transcription activator-like effectors (TALEN), clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) is currently the most efficient molecular tool for genome editing. This system, originally identified as a bacterial adaptive immune system, is capable of cutting and modifying any gene of a large number of living organisms. Numerous trials using this technology are being developed to provide effective treatment for several diseases, such as cancer, cardiovascular and ophthalmic disorders. In research, this technology is increasingly used for genetic disease modelling, providing meaningful models of relevant studies as well as a better understanding of underlying pathological mechanisms. Many molecular tools are now available to put this technique into practice in laboratories, and despite the technical and ethical issues raised by manipulation of the genome, CRIPSR/Cas9 offers a new breath of hope for therapeutic research around the world." 11/01/2018 - "By using transcription activator-like effector nuclease plasmids, tumor-associated calcium signal transducer 2 (TACSTD2) and its paralogous gene, epithelial cell adhesion molecule (EpCAM), were knocked out in HCE-T cells. "
4.	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma) 01/01/2019 - "In this study, we used transcription activator-like effector nuclease technology, to disrupt disease-causing mutant KRT10 alleles in an ex vivo cellular approach, with the intent of developing a therapy for patients with epidermolytic ichthyosis. "
5.	Hemophilia A (Haemophilia) 06/24/2014 - "In this study, we used a transcription activator-like effector nuclease (TALEN) pair to invert a 140-kbp chromosomal segment that spans the portion of the F8 gene in human induced pluripotent stem cells (iPSCs) to create a hemophilia A model cell line. "

Related Drugs and Biologics

1.	Transcription Activator-Like Effector Nucleases
2.	Zinc Finger Nucleases
3.	Proteins (Proteins, Gene)
4.	DNA (Deoxyribonucleic Acid)
5.	Transcription Factors (Transcription Factor)
6.	Cadherins (E-Cadherin)
7.	Sucrose (Saccharose)
8.	Phosphotransferases (Kinase)
9.	Nucleotides
10.	Endonucleases

Related Therapies and Procedures

1.	Therapeutics