Uncoupling Protein 1

A mitochondrial uncoupling protein that is expressed in BROWN ADIPOSE TISSUE. It is critical for NONSHIVERING THERMOGENESIS to prevent heat loss in NEONATES.

Also Known As:

BAT Uncoupling Protein; Brown Adipose Tissue Uncoupling Protein; Mitochondrial Brown Fat Uncoupling Protein 1; Mitochondrial Uncoupling Protein; SLC25A7 Protein; Solute Carrier Family 25 Member 7; Thermogenin; UCP1 Protein; Uncoupling Protein 1a; Uncoupling Protein, Mitochondrial Membrane; Uncoupling Protein, BAT; Uncoupling Protein, Mitochondrial

Networked: 362 relevant articles (12 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Steinberg, Gregory R: 5 articles (01/2021 - 02/2015)
2.	Moustaid-Moussa, Naima: 4 articles (12/2021 - 01/2019)
3.	Cinti, Saverio: 4 articles (11/2020 - 11/2007)
4.	Flachs, P: 4 articles (01/2017 - 12/2004)
5.	Yang, Hongmei: 3 articles (07/2022 - 05/2019)
6.	Zhang, Xiaoping: 3 articles (07/2022 - 05/2019)
7.	Ahn, Jiyun: 3 articles (05/2022 - 01/2016)
8.	Jastroch, Martin: 3 articles (01/2022 - 05/2015)
9.	Keipert, Susanne: 3 articles (01/2022 - 02/2008)
10.	Ma, Lei: 3 articles (01/2022 - 04/2015)

Related Diseases

1.	Obesity 10/01/2019 - "Recent studies suggested that activation of Uncoupling Protein 1 (UCP1) has become an appealing therapeutic strategy against obesity and diabetes. " 01/01/2019 - "Recent studies have shown that induction of brown-like adipocytes, also referred to as beige or brite cells, in white adipose tissue (WAT) results in the release of excess energy through mitochondrial heat production via uncoupling protein 1. This has potential a therapeutic strategy for obesity and related diseases as well as classical brown adipocytes. " 12/01/2017 - "Our study aimed to examine the mechanisms through which obesity induced by a high fat diet (HFD) affects uncoupling protein 1 (UCP1) expression via signal transduction and activator of transcription 5 (STAT5s). " 12/01/1997 - "Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity." 05/01/1996 - "C57BL6/J mice with the expression of the mitochondrial uncoupling protein (UCP) gene from the fat-specific aP2 gene promoter were used to study the mechanism by which the aP2-Ucp transgene affects adiposity and reduces high-fat diet induced obesity. "
2.	Insulin Resistance 08/08/2018 - "Because BAT mass correlates inversely with insulin resistance, we hypothesized that increased uncoupling protein 1 (UCP1) expression contributes to the superior metabolic health of females. " 03/01/2017 - "Reduced body mass, increased insulin sensitivity, decreased adipocyte size and marked expression of uncoupling protein 1 by ectopic multilocular adipocytes support these findings. " 01/01/2021 - "The reduction of brown fat UCP1 protein in GDM mice has a certain correlation with obesity tendency and obvious insulin resistance." 01/01/2020 - "Engraftment of mast cell-deficient mice with Tph1-/- mast cells or selective mast cell deletion of Tph1 enhances uncoupling protein 1 (Ucp1) expression in white adipose tissue and protects mice from developing obesity and insulin resistance. " 02/19/2008 - "Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1."
3.	Metabolic Diseases (Metabolic Disease) 06/01/2023 - "Reductions in Brown Adipose Tissue (BAT) thermogenesis, mediated in part by uncoupling protein 1 (Ucp1), are associated with metabolic diseases. " 01/01/2022 - "Brown adipose tissue (BAT) plays a critical role in energy expenditure by uncoupling protein 1 (UCP1)-mediated thermogenesis and represents an important therapeutic target for metabolic diseases. " 10/01/2014 - "Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP1), is receiving great attention because metabolically active brown adipose tissue may protect humans from metabolic diseases. " 01/01/2018 - "Brown adipose tissue (BAT) with its thermogenic function due to the presence of the mitochondrial uncoupling protein 1 (UCP1), has been positively associated with improved resistance to obesity and metabolic diseases. " 01/01/2022 - "Human brown fat is a potential therapeutic target for preventing obesity and related metabolic diseases by dissipating energy as heat through uncoupling protein 1 (UCP1). "
4.	Body Weight (Weight, Body) 10/06/2023 - "In mice with FHL2 deficiency (FHL2KO), WTD feeding resulted in reduced body weight gain paralleled by enhanced energy expenditure and uncoupling protein 1 (UCP1) expression, indicative of activated thermogenesis. " 01/01/2022 - "KEY POINTS: Exercise promotes thermogenesis by activating uncoupling protein 1 (UCP1), which leads to a decrease in the body weight gain and body fat content. " 01/01/2022 - "Thermoreceptor TRPV1 regulates body weight and blood pressure in the absence of thermogenin." 01/01/2019 - "Here, we report that cold-treated mice have higher expression of uncoupling protein 1 (UCP1) in adipose tissues and lower body weights and fat masses. " 12/01/2017 - "The null effect on body weight despite diminished feeding could be related to decreased uncoupling protein 1 (UCP-1) gene expression in brown adipose tissue (BAT). "
5.	Weight Gain 05/30/2022 - "Furthermore, FBT enhanced energy expenditure and promoted browning of subcutaneous adipose tissue by upregulating the expression of brown adipocyte-specific genes, including uncoupling protein 1. Based on these results, we suggest that FBT induces energy expenditure by promoting the browning of subcutaneous adipose tissue, which prevents weight gain." 10/01/2017 - "There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. " 09/01/2007 - "Compared with NL, SL rats showed excess weight gain, and adult SL animals had a reduced thermogenic capacity as displayed by lower levels of uncoupling protein 1 (UCP1). " 05/01/1999 - "The Trp64Arg mutation of the beta3-adrenergic receptor (beta3AR) gene and A to G polymorphism of the uncoupling protein 1 (UCP1) gene are reported to be associated with weight gain, and both have been shown to have an additive effect on weight gain in Caucasians. " 03/01/1998 - "The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and beta3-adrenergic receptor (beta3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. "

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