Snail Family Transcription Factors

A transcription factor family characterized by the presence of several C-terminal CYS2-HIS2 ZINC FINGERS. They function in many developmental processes including the induction of the EPITHELIAL-MESENCHYMAL TRANSITION; maintenance of embryonic MESODERM; growth arrest, CELL SURVIVAL; and CELL MIGRATION.

Also Known As:

Networked: 64 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Yu: 2 articles (01/2020 - 09/2017)
2.	Dorigo, Oliver: 2 articles (01/2019 - 12/2015)
3.	Qi, Dongping: 2 articles (01/2019 - 12/2015)
4.	Rowat, Amy C: 2 articles (01/2019 - 12/2015)
5.	Abrams, Natalie: 2 articles (09/2016 - 02/2016)
6.	Bonner, William M: 2 articles (09/2016 - 02/2016)
7.	Kasoji, Manjula: 2 articles (09/2016 - 02/2016)
8.	Merchant, Anand: 2 articles (09/2016 - 02/2016)
9.	Redon, Christophe E: 2 articles (09/2016 - 02/2016)
10.	Sethi, Taresh K: 2 articles (09/2016 - 02/2016)

Related Diseases

1.	Carcinoma (Carcinomatosis) 09/01/2010 - "Expression of transcription factors snail, slug, and twist in human bladder carcinoma." 05/01/2009 - "Transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma of the head and neck." 08/01/2019 - "Our present study indicates that TNFAIP3 is required for the ubiquitination degradation of epithelial-mesenchymal transition (EMT) related transcription factors Snail and ZEB1, which further altered the expression of EMT-related marker proteins and eventually contributing to the malignant phenotype and poorer prognosis of gastric carcinoma. "
2.	Fibrosis (Cirrhosis) 09/25/2022 - "Background: The aim of this study was to determine the expression of epithelial to mesenchymal transition (EMT)-related transcription factors Snail, Wnt4, and Notch2 with key roles in renal fibrosis, in different renal areas of diabetic rats: glomeruli (G), proximal and distal convoluted tubules (PCT; DCT). " 06/01/2022 - "RVOTO tissue samples were histologically analyzed for myocardial hypertrophy, fibrosis, elastin content, and active EndMT (immunohistochemical double-staining for endothelial and mesenchymal markers and transcription factors Slug/Snail) and compared to four healthy controls. "
3.	Neoplasms (Cancer) 01/01/2019 - "Epithelial-mesenchymal transition (EMT) is regulated by SNAIL family transcription factors, including Snail1 and Snail2 (Slug), and serves important roles in progression and cancer resistance to treatment. " 06/28/2001 - "To examine the possibility that transcriptional mechanisms serve as the second hit in tumors with LOH, specific pathways, including genetic variant and hypermethylation at the promoter region and abnormal expression of positive (WT1) and negative (Snail) transcription factors, were identified. " 10/27/2021 - "We used three GSC cultures and glioma resections to examine the expression, regulation, and role of two transcription factors, SLUG (SNAI2) and TAL1 (SCL), involved in epithelial to mesenchymal transition (EMT), hematopoiesis, vascular identity, and treatment resistance in various cancers. " 08/15/2007 - "The transcription factors Snail and Slug are expressed in pancreatic cancer but not in normal tissue, suggesting a role in the progression of human pancreatic tumors. " 04/01/2004 - "In breast carcinomas, Snail transcription factors have been linked to tumor progression and invasiveness. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "Thus, we show for the first time that the overexpressed PLD2 in human breast tumors is regulated by Slug and Snail transcription factors. " 06/01/2011 - "Also, transcription factors Snail and Slug were upregulated in breast cancer cells overexpressing MTDH. " 06/01/2005 - "Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer." 04/01/2004 - "Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression." 04/01/2004 - "In breast carcinomas, Snail transcription factors have been linked to tumor progression and invasiveness. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "CBX6 Promotes HCC Metastasis Via Transcription Factors Snail/Zeb1-Mediated EMT Mechanism." 01/01/2020 - "By suppressing PPARG, miR-27b-3p could also activate transcription factors Snail and NF-κB, thereby promoting metastasis. " 10/18/2023 - "Snail transcription factors as key regulators of chemoresistance, stemness and metastasis of ovarian cancer cells." 03/01/2013 - "Furthermore, inhibition of the Hh signaling pathway significantly inhibited EMT by suppressing the activation of transcription factors Snail and Slug, which are correlated with significantly reduced pancreatic cancer cell invasion, suggesting that the Hh signaling pathway is involved in early metastasis. " 10/01/2011 - "Furthermore, a number of genes/factors involved in migration, invasion and metastasis were affected including transcription factors (snail, snail2, and twist) and osteopontin, an ECM molecule involved in metastasis. "

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