Pyrin Domain-Containing 3 Protein NLR Family

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

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Networked: 99 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Yan: 3 articles (03/2021 - 01/2018)
2.	Latz, Eicke: 3 articles (10/2020 - 02/2015)
3.	Hua, Kuo-Feng: 3 articles (01/2020 - 01/2019)
4.	Ju, Tz-Chuen: 3 articles (01/2020 - 01/2019)
5.	Li, Lan-Hui: 3 articles (01/2020 - 01/2019)
6.	Wang, Zheng: 2 articles (11/2022 - 01/2020)
7.	Chen, Fang-Hsin: 2 articles (01/2020 - 01/2019)
8.	Chernikov, Oleg V: 2 articles (01/2020 - 01/2019)
9.	Chiu, Hsiao-Wen: 2 articles (01/2020 - 01/2019)
10.	Hsieh, Chih-Yu: 2 articles (01/2020 - 01/2019)

Related Diseases

1.	Lung Injury 11/01/2018 - "Dex treatment significantly attenuated lung injury and inhibited the expression levels of the inflammation factors via reducing the level of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and autocleavage of caspase-1. " 11/01/2022 - "Compared with the LPS group, the degree of lung injury in the overexpression HSF1+LPS group was significantly improved, the lung W/D ratio was significantly reduced (4.76±0.16 vs. 6.93±0.33, P < 0.05), the macrophage infiltration was reduced, PaO2/FiO2 increased significantly [mmHg (1 mmHg ≈ 0.133 kPa): 397.62±19.46 vs. 280.12±37.42, P < 0.05], HSF1 protein expression was significantly up-regulated in lung tissue and AM (HSF1/GAPDH: 0.90±0.04 vs. 0.61±0.04 in lung tissue, 1.10±0.10 vs. 0.57±0.08 in AM, both P < 0.05), NLRP3 protein expression was significantly down-regulated (NLRP3/GAPDH: 0.75±0.14 vs. 1.05±0.11 in lung tissue, 0.81±0.09 vs. 1.14±0.17 in AM, both P < 0.05), and the contents of IL-1β and IL-18 in BALF and AM medium were significantly decreased [IL-1β (ng/L): 7.82±0.45 vs. 14.09±0.58 in BALF, 11.11±0.46 vs. 16.66±0.96 in AM; IL-18 (ng/L): 50.44±3.30 vs. 66.31±5.67 in BALF, 43.95±0.88 vs. 73.52±1.23 in AM, all P < 0.05]. " 03/28/2022 - "Compared with the chlorogenic acid group, the lung W/D value, lung injury score, and inflammatory factor levels in the bronchoalveolar lavage fluid were significantly increased in the chlorogenic acid+miR-223 antagomir group (all P<0.05); lung tissue damage was aggravated; the number of EOS, lymphocytes and neutrophils in bronchoalveolar lavage fluid significantly increased (all P<0.05); the expression levels of miR-223 in lung tissues were significantly decreased (P<0.05); and the expression levels of NLRP3 protein were significantly increased (P<0.05). " 03/28/2022 - "Compared with the model group, the W/D value of lungs, lung injury score, and levels of inflammatory factors in bronchoalveolar lavage fluid were significantly decreased in the chlorogenic acid group, the chlorogenic acid+miR-223 NC group, and the chlorogenic acid+miR-223 antagomir group (all P<0.05); lung tissues damage was alleviated; the numbers of EOS, lymphocytes, and neutrophils in bronchoalveolar lavage fluid were significantly decreased (all P<0.05); the expression levels of miR-223 in lung tissues were significantly increased (P<0.05); and the expression levels of NLRP3 protein were significantly decreased (P<0.05). " 12/01/2021 - "Our findings demonstrated that extracellular citrate aggravated the pathological lung injury induced by LPS in mice, characterized by up-regulation of pro-inflammatory factors and over-activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in the lungs. "
2.	Body Weight (Weight, Body) 11/01/2022 - "Orally supplemental zinc reduced (P = 0.007) the bacterial load in the liver and improved (P < 0.05) the body weight, the bursa index, the serum IgA content, the villus height/crypt depth ratio, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) protein expression, as well as tended to increase (P = 0.064) the protein abundance of caspase-1 of the jejunum, but did not alleviate the high level of neutrophil proportion and IL-1β mRNA expression of the jejunum (P > 0.05). "
3.	Inflammation (Inflammations) 01/01/2023 - "This study identifies a novel compound JNUTS013 that inhibits inflammation through inducing NLRP3 protein degradation in vitro and in vivo, which not only supports the development of JNUTS013 as an anti-inflammation agent but also creates a new way for the treatment of inflammation by chemically inducing NLRP3 degradation." 01/01/2023 - "A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation." 09/01/2022 - "Additionally, the inflammation induced by the oxidative stress was attenuated by the SSA and AF via inhibition of the NLRP3 protein expression. " 11/01/2021 - "Among the differentiallyexpressedproteins involved in inflammation, the NLRP3 protein level increased dramatically. " 01/01/2019 - "Mechanistically, Dex attenuated H2O2-mediated activation of NF-κB and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3), both of which play key roles in inflammation and inflammatory damage. "
4.	Fibrosis (Cirrhosis) 11/01/2017 - "The aim of this study was to investigate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in a mouse model of chronic pancreatitis (CP). " 07/11/2014 - "Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome."
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 07/15/2010 - "To investigate the role of NLRP3 protein in MS, we used a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). " 10/01/2018 - "In this study, we evaluated the effects of TMP on the inflammatory response in experimental autoimmune encephalomyelitis (EAE), which is an animal model of MS. TMP (30 mg/kg) treatment significantly reduced the expression levels of NLR Family, Pyrin Domain-Containing 3 Protein inflammasome and caspase-1and decreased inflammatory infiltration and glial activation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Interleukin-18 (Interleukin 18)
3.	NLR Proteins
4.	Messenger RNA (mRNA)
5.	Zinc
6.	Immunoglobulin A (IgA)
7.	Inflammasomes
8.	Caspase 1 (ICE Protease)
9.	Thymidine Monophosphate (TMP)
10.	Purinergic Receptors (Receptors, Purine)

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Photochemotherapy (Photodynamic Therapy)
3.	Moxibustion