Autophagy-Related Protein 8 Family

UBIQUITIN-like modifier proteins that function in CYTOPLASM to VACUOLE transport (Cvt), vesicle transport within the GOLGI APPARATUS, and AUTOPHAGOSOME biogenesis. They are also required for selective autophagic degradation of the nucleus (nucleophagy) and MITOPHAGY.

Also Known As:

ATG8 Family Proteins; ATG8 Proteins; GABARAPL2 Protein; Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 2; Autophagy Related Protein 8 Family; Family Protein, ATG8; Gamma Aminobutyric Acid Receptor Associated Protein Like 2; Protein, ATG8; Protein, ATG8 Family; ATG8 Family Protein; ATG8 Protein

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ancion, Marie: 1 article (09/2021)
2.	Baguet, Aurélie: 1 article (09/2021)
3.	Baudu, Timothée: 1 article (09/2021)
4.	Despouy, Gilles: 1 article (09/2021)
5.	Feugeas, Jean-Paul: 1 article (09/2021)
6.	Fraichard, Annick: 1 article (09/2021)
7.	Guittaut, Michaël: 1 article (09/2021)
8.	Herfs, Michaël: 1 article (09/2021)
9.	Hervouet, Eric: 1 article (09/2021)
10.	Jacquet, Marine: 1 article (09/2021)

Related Diseases

1.	Malaria 01/01/2023 - "Malaria parasites such as Plasmodium falciparum are a unique system to study a novel, nonautophagic function of Atg8 separate from its role in autophagy: they have only one Atg8 protein whose only essential function is in the inheritance of the apicoplast, a unique secondary plastid organelle. " 01/01/2023 - "The malaria parasite Plasmodium falciparum offers a unique opportunity to study nonautophagic functions of Atg8 family proteins because it encodes a single Atg8 homolog whose only essential function is in the inheritance of an unusual secondary plastid called the apicoplast. " 01/01/2012 - "Here, we report the biochemical properties and subcellular localization of the Atg8 protein of the human malaria parasite Plasmodium falciparum (PfAtg8). "
2.	Neoplasms (Cancer) 09/24/2021 - "The pathway of selective autophagy, leading to a targeted elimination of specific intracellular components, is mediated by the ATG8 proteins, and has been previously suggested to be involved in the regulation of the Epithelial-mesenchymal transition (EMT) during cancer's etiology. " 12/17/2019 - "These findings provide mechanistic insight into RTK recruitment to autophagosomes and establish distinct roles for ATG8 proteins in this process, supporting that differential expression of ATG8 proteins can shape the functional consequences of autophagy in cancer development and progression." 01/01/2019 - "The tumor protein p53-inducible nuclear protein 2 (TP53INP2) has been reported to participate in autophagy by interacting with autophagosome-localized autophagy-related protein 8 (Atg8) family proteins, including LC3. "
3.	Infections 10/24/2019 - "Overexpression of Atg8 (Atg8-OE) rendered the parasites resistant to stress and capable of infecting macrophages in substantial numbers; however, disruption of the Atg8 gene (ΔAtg8) resulting in suppression of Atg8 protein expression, increased susceptibility to stress and reduced the capability to cause infection. " 11/23/2012 - "Thus, intracellular pathogens can inhibit autophagy by irreversibly inactivating Atg8 proteins during infection."
4.	Starvation 04/03/2017 - "Our work clarifies the essential contribution of Atg8 family proteins to autophagy in promoting autolysosome formation, and reveals the GABARAP subfamily as a key driver of starvation-induced autophagy and PINK1-PARK2-dependent mitophagy. " 04/03/2017 - "To dissect the functions of LC3/GABARAPs during starvation-induced autophagy and PINK1-PARK2/Parkin-dependent mitophagy, we used CRISPR/Cas9 gene editing to generate knockouts of the LC3 and GABARAP subfamilies, and all 6 Atg8 family proteins in HeLa cells. "
5.	Parkinson Disease (Parkinson's Disease) 06/20/2023 - "ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nuclear Proteins (Protein, Nuclear)
3.	Autophagy-Related Proteins