Nogo Proteins

Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.

Also Known As:

NI-220 Protein; NI-250 Protein; NI-35 Protein; NI-35-250; Neurite Growth Inhibitor 35-350; Nogo Protein; Nogo-66 Protein; Nogo-A Protein; Nogo-B Protein; Nogo-C Protein; Reticulon 4-B Protein; Reticulon-4 Protein; NI 220 Protein; NI 250 Protein; NI 35 250; NI 35 Protein; Neurite Growth Inhibitor 35 350; Nogo 66 Protein; Nogo A Protein; Nogo B Protein; Nogo C Protein; Reticulon 4 B Protein; Reticulon 4 Protein

Networked: 37 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Myelin Proteins: 746
      - Nogo Proteins: 37
        human RTN4 protein
        mouse Rtn4 protein
        rat Rtn4 protein
        Xenopus Rtn4 protein
  - Nerve Tissue Proteins: 2
    - Myelin Proteins: 746
      - Nogo Proteins: 37
        human RTN4 protein
        mouse Rtn4 protein
        rat Rtn4 protein
        Xenopus Rtn4 protein

Experts

1.	Nie, Hu: 2 articles (04/2022 - 11/2016)
2.	Cheng, Li-Hong: 1 article (05/2022)
3.	Hong, Dong-Ying: 1 article (05/2022)
4.	Min, You-Jiang: 1 article (05/2022)
5.	Wang, Zhi-Qin: 1 article (05/2022)
6.	Yao, Hai-Hua: 1 article (05/2022)
7.	Ye, Wen-Guo: 1 article (05/2022)
8.	Cao, Yu: 1 article (04/2022)
9.	Li, Jia-Li: 1 article (04/2022)
10.	Chan, Sun-On: 1 article (09/2021)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2023 - "Information about the effects of other ligands of Nogo protein on the CNS are yet to be discovered however several pieces of evidence have suggested that it may also influence the neuronal maturation of CNS and targeting Nogo-A could prove to be beneficial in several neurodegenerative diseases."
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/01/2009 - "Previous findings demonstrate that neutralization of Nogo, a protein originally identified as a myelin-associated inhibitor (MAI) of axon regeneration, ameliorates experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS. More efficient axonal regeneration was suggested as a mechanism underlying the improved EAE outcome. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 05/01/2016 - "The specific myelin component Nogo protein is one of the major inhibitory molecules of spinal cord axonal outgrowth following spinal cord injury. " 06/01/2007 - "Nogo A protein neutralisation and motor cortex computer implants: a future hope for spinal cord injury." 06/15/2006 - "Therapeutically, targeting the Nogo-A protein by means of the immune response has been tried in an attempt to block neurite growth inhibition and promote regeneration in spinal cord injury models; the immune response to Nogo-A, however, has not been extensively studied. " 12/15/2014 - "Because the inhibition of Nogo proteins can promote neurite growth and nerve cell differentiation, a cell-scaffold complex seeded with Nogo receptor (NgR)-silenced neural stem cells and Schwann cells may be able to improve the microenvironment for spinal cord injury repair. " 02/15/2013 - "Methylprednisolone inhibits Nogo-A protein expression after acute spinal cord injury."
4.	Neoplasms (Cancer) 07/12/2023 - "The reticulon-4 (RTN4) gene, encoding Nogo proteins, plays a critical role in apoptosis and cancer development, with genetic variations affecting its function. " 01/01/2018 - "Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. " 01/01/2014 - "Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. " 02/01/2011 - "We also confirmed the overexpression of the Nogo-A protein in 53 astrocytic and oligodendroglial tumors using Western blot analysis. " 06/15/2006 - "In recent years, knowledge about the physiological functions of the Nogo-A protein has grown considerably, and this molecule has evolved from being one of the most important axonal regrowth inhibitors present in central nervous system (CNS) myelin, to several other potentially important roles in different areas such as nervous system development, epilepsy, vascular physiology, muscle pathology and CNS tumors. "
5.	Vascular Remodeling 02/17/2011 - "Recently, we identified the Rtn-4B (Nogo-B) protein in endothelial and smooth muscle cells of the vessel wall, and showed that Nogo-B is a regulator of cell migration in vitro and vascular remodeling and angiogenesis in vivo. " 07/01/2007 - "Nogo proteins have received intense attentions because they have been implicated in a variety of critical cellular processes including CNS neuronal regeneration, vascular remodeling, apoptosis, interaction with beta-amyloid protein converting enzyme, and generation/maintenance of the tubular network of the endoplasmic reticulum (ER). "

Related Drugs and Biologics

1.	Ligands
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Biomarkers (Surrogate Marker)
5.	Glial Fibrillary Acidic Protein
6.	Enzymes
7.	Collagen
8.	Oligodendrocyte-Myelin Glycoprotein
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Semaphorin-3A

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Resuscitation
3.	Moxibustion