Morton Neuroma

A nerve inflammation in the foot caused by chronic compression of the plantar nerve between the METATARSAL BONES.

Also Known As:

Intermetatarsal Neuroma; Morton's Disease; Morton's Metatarsalgia; Morton's Neuralgia; Morton's Neuroma; Disease, Morton's; Intermetatarsal Neuromas; Metatarsalgia, Morton's; Morton Disease; Morton Metatarsalgia; Morton Neuralgia; Mortons Disease; Mortons Metatarsalgia; Mortons Neuralgia; Mortons Neuroma; Neuralgia, Morton's; Neuroma, Intermetatarsal; Neuroma, Morton; Neuroma, Morton's; Neuromas, Intermetatarsal

Networked: 141 relevant articles (26 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neuroma
3.	Tendinopathy (Tendonitis)
4.	Metatarsalgia
5.	Plantar Fasciitis

Experts

1.	Beggs, Ian: 3 articles (02/2022 - 05/2013)
2.	Choi, Jun Young: 2 articles (06/2022 - 06/2021)
3.	Hong, Woi Hyun: 2 articles (06/2022 - 06/2021)
4.	Suh, Jin Soo: 2 articles (06/2022 - 06/2021)
5.	Albano, Domenico: 2 articles (02/2022 - 07/2021)
6.	McNally, Eugene: 2 articles (02/2022 - 07/2012)
7.	Messina, Carmelo: 2 articles (02/2022 - 07/2021)
8.	Sconfienza, Luca Maria: 2 articles (02/2022 - 07/2021)
9.	Magnan, Bruno: 2 articles (04/2020 - 01/2020)
10.	Choi, Gi Won: 2 articles (04/2019 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Morton Neuroma:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/2021 - "Efficacy of a Single Corticosteroid Injection for Morton's Neuroma in Adults: A Systematic Review." 01/01/2009 - "The first-line treatment for symptomatic Morton's neuroma in our hospital is a perineural ultrasound-guided injection of corticosteroid and local anaesthetic (USI). " 10/01/2003 - "A painful interdigital space, such as that occurring in patients with Morton's neuroma, is commonly relieved with corticosteroid injection. " 07/01/2021 - "The aim of this study was to systematically synthesize the evidence relating to the effectiveness of a corticosteroid injection for Morton's neuroma. " 01/01/2018 - "The aim of this study was to identify the risk factors and cut-off values that predict failure of corticosteroid injection in treatment of Morton's neuroma. "
2.	Ethanol (Ethyl Alcohol)IBA 01/01/2020 - "Improved Injection Technique of Ethanol for Morton's Neuroma." 11/01/2014 - "The lack of any measureable changes in nerve or adjacent muscle histology with ethanol injection into the rat sciatic nerve (and surrounding tissues) raises questions about the efficacy of using ethanol injections in the treatment of Morton's neuroma in human clinical practice." 09/01/2020 - "Histologic changes are seen in Morton's neuroma with the use of 4% ethanol sclerosing injection, contrary to findings from previous studies." 09/01/2020 - "Effects of 4% Ethanol Sclerosing Injection on Morton's Neuroma: A Histologic Study."
3.	Local AnestheticsIBA 04/01/1998 - "To determine the outcome of surgical excision of Morton's neuroma after a local anesthetic diagnostic block into the neuroma has relieved symptoms. " 09/01/2017 - "The purpose of this study was to compare the effectiveness between corticosteroid injection associated with local anesthetic and local anesthetic alone (placebo control group) for the treatment of Morton's neuroma. " 09/01/2017 - "Forty-one patients with a diagnosis of Morton's neuroma were randomized to receive 3 injections of either a corticosteroid plus a local anesthetic or a local anesthetic alone. " 09/01/2017 - "The injection of a corticosteroid plus a local anesthetic was not superior to a local anesthetic alone in terms of pain and function improvement in patients with Morton's neuroma. "
4.	SteroidsIBA 01/01/2015 - "So, we aimed to evaluate whether steroid injection is cost-effective in treating Morton's neuroma compared with anaesthetic injection alone. " 04/01/2007 - "Although some studies have suggested that neither injection nor imaging have a role in the treatment of Morton's neuroma, this study, however, demonstrates that ultrasound guided placement of local anaesthetic and steroid in either an intermetatarsal bursa or Morton's neuroma gives a good short and medium-term symptom relief and in the majority of cases avoids or at least delays the need for surgery." 05/01/2013 - "Steroid injection for Morton neuroma - data-based justification." 06/01/2010 - "A control group of 11 feet were assessed from patients with a clinical diagnosis of Morton's neuroma (no instability) and successfully treated with a single steroid injection. " 04/01/2007 - "Patients clinically diagnosed with interdigital Morton's neuroma were treated with ultrasound guided injection of local anaesthetic and steroid. "
5.	Capsaicin (Zostrix)FDA Link 11/01/2016 - "Recently injection of capsaicin showed therapeutic efficacy in patients with Morton's neuroma, a painful foot condition associated with compression of one of the digital nerves. " 06/01/2016 - "These findings suggest that injection of capsaicin is an efficacious treatment option for patients with painful intermetatarsal neuroma. " 06/01/2016 - "A randomized, double-blind, placebo-controlled trial of injected capsaicin for pain in Morton's neuroma." 04/01/2009 - "Overall, some molecules (e.g., capsaicin) demonstrated potential analgesia in certain conditions (postsurgical pain, postherpetic neuralgia, pain in diabetic neuropathy, osteoarthritis, bunionectomy, and Morton's neuroma), whereas others fell out of the clinic due to on-target liabilities or failed to demonstrate efficacy. " 04/01/2009 - "Clinical trial results of TRPV1 agonists such as resiniferatoxin in interstitial cystitis, NGX 4010 in post-herpetic neuralgia, and 4975 (Adlea) in osteoarthritis, bunionectomy, and Morton's neuroma have been reported. "
6.	mesoglycanIBA 01/01/2018 - "In accordance with the PRISMA guidelines, we performed a comprehensive literature search to identify studies measuring the efficacy of the surgical treatment of painful neuromas in the extremities (excluding Morton's neuroma and compression neuropathies). "
7.	Anesthetics (Anesthetic Agents)IBA 05/01/2013 - "Our primary research aim was to determine whether corticosteroid injection is an effective treatment for Morton neuroma compared with an anesthetic injection as a placebo control. " 02/19/2014 - "An injection of corticosteroid plus anesthetic was more effective than anesthetic alone for Morton neuroma." 05/01/2013 - "One hundred and thirty-one participants with Morton neuroma (mean age, fifty-three years; 111 [85%] female) were randomized to receive either corticosteroid and anesthetic (1 mL methylprednisolone [40 mg] and 1 mL 2% lignocaine) or anesthetic alone (2 mL 1% lignocaine). "
8.	GadoliniumIBA 01/01/1997 - "MR scans with gadolinium were sometimes helpful when the differential diagnosis included synovitis, Morton's neuroma or intramuscular myxoma, and when it was important to differentiate cystic from solid lesions. "
9.	Sclerosing Solutions (Sclerosing Agents)IBA 09/01/2020 - "Nonoperational treatments for Morton's neuroma remain controversial because it is believed that sclerosing injections do not change nerve fibers on a cellular level. " 11/01/1999 - "The treatment of intermetatarsal neuromas with 4% alcohol sclerosing injections." 11/01/1999 - "In this study, 100 adult patients with previously untreated intermetatarsal neuromas received three to seven injections of a 4% alcohol sclerosing solution every 5-10 days. " 06/01/2018 - "Thus, this review found insufficient high-quality research evidence to afford conclusions on the management of intermetatarsal neuromas with alcohol sclerosing agent injections." 09/01/2020 - "Histologic changes are seen in Morton's neuroma with the use of 4% ethanol sclerosing injection, contrary to findings from previous studies."
10.	Methylprednisolone FDA LinkGeneric 05/01/2013 - "Methylprednisolone injections for the treatment of Morton neuroma: a patient-blinded randomized trial." 01/01/2015 - "Cost-effectiveness of steroid (methylprednisolone) injections versus anaesthetic alone for the treatment of Morton's neuroma: economic evaluation alongside a randomised controlled trial (MortISE trial)." 05/01/2013 - "One hundred and thirty-one participants with Morton neuroma (mean age, fifty-three years; 111 [85%] female) were randomized to receive either corticosteroid and anesthetic (1 mL methylprednisolone [40 mg] and 1 mL 2% lignocaine) or anesthetic alone (2 mL 1% lignocaine). "

Therapies and Procedures

1.	Injections 12/01/2022 - "This work compares the effectiveness of blind versus ultrasound (US)-guided injections for Morton neuroma (MN) up to 3 years of follow-up. " 02/01/2019 - "• Ultrasound-guided injections in Morton's neuroma lead to a lower percentage of skin side effects than blind injections." 06/01/2018 - "Some authors have supported the use of alcohol sclerosing intra-lesional injections to treat intermetatarsal neuromas. " 06/01/2018 - "Sclerosing alcohol injections for the management of intermetatarsal neuromas: A systematic review." 12/01/2014 - "The injections are useful not only for the treatment but also for diagnosis of Morton's disease. "
2.	Decompression 01/01/2020 - "Dellon's decompression method yielded a highly positive outcome, and based on our findings, we consider it a reliable, technically simple and promising approach to treat Morton's neuroma. " 11/01/2020 - "This study describes the technique for decompression of the intermetatarsal nerve in Morton's neuroma by ultrasound-guided surgical resection of the transverse intermetatarsal ligament. " 01/01/2020 - "All patients with a clinical diagnosis of Morton's neuroma, verified by MRI and treated by nerve decompression were included in this study in the years from 2010 to 2018 at our department. " 01/01/2020 - "As there are no current studies dealing with Dellon's surgical technique, we carried out a retrospective analysis with the aim of showing that nerve decompression is an effective method to treat Morton's neuroma, and one that considers its true pathology. " 08/01/2022 - "A total of 12 patients underwent isolated IML decompression for Morton's neuroma with an average follow-up of 13.5 months. "
3.	Extracorporeal Shockwave Therapy 05/01/2009 - "We sought to evaluate the safety and effectiveness of extracorporeal shockwave therapy as a therapeutic treatment for destroying Morton's neuroma. " 03/01/2016 - "Extracorporeal Shockwave Therapy in Patients with Morton's Neuroma A Randomized, Placebo-Controlled Trial." 05/01/2009 - "Extracorporeal shockwave therapy is a possible alternative to surgical excision for Morton's neuroma." 03/01/2016 - "The aim of this study was to evaluate the efficacy of extracorporeal shockwave therapy (ESWT) for the treatment of Morton's neuroma by measuring changes in patient pain, function, and neuroma size. "
4.	Denervation 03/01/2016 - "Despite the development of less invasive techniques and very good outcomes in a short period of time, long-term results have shown that neurectomy is still useful in the treatment of Morton's neuroma. " 10/06/2022 - "The purpose of this study was to investigate and compare the clinical outcomes of neurectomy in the treatment of Morton's neuroma through plantar and dorsal approaches. " 06/01/2022 - "This review aimed to evaluate the effects of operative treatments for Morton's neuroma other than neurectomy using an algorithmic approach and a structured critical framework to assess the methodological quality of reported studies. " 06/01/2022 - "The effectiveness of operative treatments other than neurectomy for Morton's neuroma remains debatable despite several reported studies. " 01/01/2016 - "This study supports the use of either the plantar or dorsal approach for the resection of Morton neuroma and suggests that a plantar approach for neurectomy can produce satisfactory results."
5.	Osteotomy 11/10/2023 - "The purpose of this study is to investigate the post-operative pedobarographic changes of sliding osteotomy of the 3rd metatarsal bone for treating Morton's neuroma. " 12/01/2022 - "The aim of this study was to evaluate the outcome of minimally invasive distal metatarsal metaphyseal osteotomy (DMMO) and percutaneous release of the deep transverse metatarsal ligament (DTML) in patients with Morton's neuroma. " 11/01/2017 - "This study describes the clinical outcome of sliding osteotomy on the proximal metatarsal bone for the treatment of Morton's neuroma. " 11/10/2023 - "Forty patients (45 feet) who underwent metatarsal sliding osteotomy of the 3rd metatarsal bone for treating Morton's neuroma from November 2013 to December 2021 were retrospectively reviewed. " 11/10/2023 - "Various operative methods for the treatment of Morton's neuroma have been discussed, and osteotomy of the metatarsal bone has been reported recently. "