Type VI Secretion Systems

Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex.

Also Known As:

Bacterial Secretion System, Type VI; T6SS Secretion Systems; Type 6 Secretion System; Type 6 Secretion Systems; Type VI Secretion System; Secretion Systems, T6SS; Systems, T6SS Secretion

Networked: 89 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Protein Translocation Systems: 7
    - Bacterial Secretion Systems: 16
      - Type VI Secretion Systems: 89

Experts

1.	Geng, Zhi: 4 articles (10/2021 - 01/2019)
2.	She, Zhun: 4 articles (10/2021 - 01/2019)
3.	Bröms, Jeanette E: 4 articles (01/2017 - 01/2012)
4.	Sjöstedt, Anders: 4 articles (01/2017 - 01/2012)
5.	Dong, Yuhui: 3 articles (10/2021 - 05/2020)
6.	Liu, Qin: 3 articles (10/2019 - 10/2018)
7.	Yang, Dahai: 3 articles (10/2019 - 10/2018)
8.	Zhang, Yuanxing: 3 articles (10/2019 - 10/2018)
9.	Chopra, Ashok K: 3 articles (01/2017 - 12/2010)
10.	Kirtley, Michelle L: 3 articles (01/2017 - 12/2010)

Related Diseases

1.	Ulcer 08/17/2012 - "The study describes the identification of type VI secretion systems (T6SSs) in Moritella viscosa, the aetiological agent of winter ulcer disease. "
2.	Glanders 01/01/2010 - "Recent studies have shown that the cluster 1 type VI secretion system (T6SS-1) expressed by this organism is essential for survival in a hamster model of glanders. "
3.	Infections 10/30/2023 - "The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like mechanism to inject effectors into target cells to benefit the infection process. " 01/01/2023 - "Finally, plant infection may be conducted through type VI secretion systems and modulation of plant cell wall synthesis. " 10/01/2022 - "At the later time points, high expression levels of a type 6 secretion system that likely prepares for a new infection cycle after lysing its host, were found. " 10/01/2021 - "The bacterial type VI secretion system (T6SS) is a powerful arsenal that fires many toxic effectors into neighboring cells to gain advantage over inter-bacterial competition and eukaryotic host infection. " 10/01/2021 - "The bacterial type VI secretion system (T6SS) secretes many toxic effectors to gain advantage in inter-bacterial competition and for eukaryotic host infection. "
4.	Persistent Infection 01/01/2023 - "The type VI secretion systems (T6SSs) have been shown to associate with chronic infections. " 01/01/2018 - "Traits associated with chronic infection include growth as a biofilm, reduced motility, and expression of a type VI secretion system (T6SS). " 12/01/2011 - "Furthermore, a retS mutation leads to repression of the T3SS, but also upregulates the type VI secretion system (T6SS), which is associated with chronic infections. " 11/12/2010 - "The type VI secretion system (T6SS) contributes to the virulence of Burkholderia cenocepacia, an opportunistic pathogen causing serious chronic infections in patients with cystic fibrosis. " 11/01/2015 - "aeruginosa PAK led to increased exopolysaccharide production and upregulation of the type VI secretion system; in turn, it repressed the type III secretion system, which is a hallmark of chronic infections and persistence for P. "
5.	Sepsis (Septicemia) 09/01/2023 - "Clinical impact of the type VI secretion system on clinical characteristics, virulence and prognosis of Acinetobacter baumannii during bloodstream infection." 01/01/2022 - "Virulence Genotype and Correlation of Clinical Severeness with Presence of the Type VI Secretion System in Klebsiella pneumoniae Isolates Causing Bloodstream Infections." 11/01/2020 - "Epidemiology and molecular characteristics of the type VI secretion system in Klebsiella pneumoniae isolated from bloodstream infections." 03/29/2018 - "Type VI secretion systems (T6SSs) contribute to the pathogenicity of avian pathogenic Escherichia coli (APEC), one of the leading causative agents of sepsis and meningitis in poultry. "

Related Drugs and Biologics

1.	Type III Secretion Systems
2.	Virulence Factors (Pathogenicity Factors)
3.	Proteins (Proteins, Gene)
4.	Carrier Proteins (Binding Protein)
5.	Adenosine Triphosphate (ATP)
6.	Inflammasomes
7.	Metalloproteases (Metalloproteinases)
8.	Cytokines
9.	Zinc
10.	Attenuated Vaccines