Quetiapine Fumarate (Seroquel)

A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.

Also Known As:

Seroquel; 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt); ICI 204,636; ICI 204636; ICI-204636; Quetiapine; ICI204636

Networked: 2830 relevant articles (433 outcomes, 868 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Calabrese, Joseph R: 41 articles (01/2022 - 11/2004)
2.	Eriksson, Hans: 33 articles (02/2020 - 03/2009)
3.	Vieta, Eduard: 32 articles (01/2021 - 10/2002)
4.	Ketter, Terence A: 30 articles (01/2022 - 07/2005)
5.	Gao, Keming: 29 articles (01/2021 - 01/2005)
6.	Brecher, Martin: 26 articles (05/2010 - 07/2003)
7.	Correll, Christoph U: 24 articles (01/2022 - 01/2007)
8.	Paulsson, Björn: 21 articles (02/2014 - 12/2004)
9.	Leucht, Stefan: 20 articles (01/2022 - 04/2007)
10.	Loebel, Antony: 20 articles (01/2022 - 04/2013)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/01/1999 - "From these results, quetiapine fumarate was suggested to be highly effective and safe for the treatment of schizophrenia." 04/01/2007 - "The efficacy of quetiapine in reducing positive and negative symptoms of schizophrenia has been proven in several clinical trials with placebo-controlled comparators. " 01/01/1999 - "Quetiapine was found to be effective against both positive and negative symptoms of schizophrenia, and had an excellent safety profile. " 01/01/2011 - "Short-term clinical studies have shown that quetiapine XR (400-800 mg/d) is efficacious in the acute treatment of schizophrenia, while a long-term study has shown that quetiapine XR was significantly more effective than placebo at preventing relapse. " 11/01/2010 - "In conclusion, this naturalistic study showed that adherence to quetiapine treatment was high, and treatment was effective in schizophrenia patients during long-term treatment. "
2.	Bipolar Disorder (Manic Depressive Psychosis) 01/01/2012 - "In bipolar disorder, quetiapine XR has also proven effective in relieving acute depressive and manic symptoms. " 12/01/2008 - "Quetiapine monotherapy is effective in improving impairment in important aspects of life that accompany improvements in depressive symptoms in patients with acute bipolar depression." 10/01/2010 - "The aim of this study was to evaluate the tolerability and efficacy of rapid quetiapine loading in youth diagnosed with pediatric bipolar disorder (PBD). " 08/15/2013 - "Adjunctive quetiapine demonstrated significantly greater improvement than placebo in Clinical Global Impression for Bipolar Disorder Overall Severity scores (F(1)=10.12, p=.002) and MADRS scores (F(1)=6.93, p=.0138), but no significant differences were observed for YMRS scores (F(1)=3.68, p=.069). " 11/01/2009 - "The results of these data demonstrated quetiapine's efficacy in the treatment of depressive phases of bipolar disorder, including statistically significant improvement in the Montgomery-Asberg Depression Rating Scale (MADRS). "
3.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2004 - "A 52-week, open-label trial of quetiapine (median dose = 138 mg/day) in elderly patients with psychosis suggested good tolerability with apparent behavioral benefit; EPS improved or remained unchanged in most patients. " 11/01/2005 - "Based on the results of this study, it appears that quetiapine is an efficacious and safe treatment for geriatric inpatients with psychosis, however, there is a wide dosing range and optimal dosage is diagnosis-dependent." 10/01/2004 - "The administration of quetiapine in doses of 25-50 mg/day brought about an important improvement in the control over the signs of parkinsonian psychoses in our patients. " 08/01/2005 - "Quetiapine, up to 200 mg daily, was well tolerated and did not worsen UPDRS scores; however, there was no significant improvement in psychosis rating scales compared to placebo. " 12/01/2016 - "Clinicians prefer quetiapine for its theoretically better safety profile, although there is no evidence for efficacy in treating psychosis. "
4.	Mania (Manias) 01/01/2007 - "Quetiapine as monotherapy, or in combination with Li or DVP, was a highly effective treatment for acute mania, as shown by overall change scores in the total YMRS. " 01/01/2007 - "Quetiapine was associated with significantly higher response and remission/euthymia rates compared with placebo with most criteria used, in patients with acute mania at the end of both 3 and 12 weeks." 06/01/2009 - "Safety, tolerability and efficacy of a rapid dose escalation of quetiapine in bipolar I mania: the FATIMA study." 06/01/2009 - "Rapid dose escalation of quetiapine to 800 mg/day over 4 days was well tolerated and effective in reducing symptoms within 5 days in acutely ill bipolar I patients with a manic episode." 01/01/2007 - "At Days 21 and 42, quetiapine combined with Li/DVP compared to Li/DVP monotherapy yielded significant, sustained improvements in the rate of clinical remission/euthymia in patients with bipolar mania. "
5.	Delirium 11/01/2020 - "Significant improvement was associated with age of 75 or older (ES = 0.07), better performance status (0.32), longer estimated prognosis (0.25), psycho-oncological consultation settings (0.20), hyperactive (0.14) or mix-motor subtypes (0.24) of delirium, and quetiapine administration (0.19); significant deterioration was observed in patients with "days" prognosis (0.18). " 10/01/2007 - "The efficacy of quetiapine on delirium was evaluated by using the Delirium Rating Scale (DRS) and the Clinical Global Impression-Severity scale (CGI-S). " 04/01/2013 - "Quetiapine appears to be an effective and safe agent for the treatment of delirium in both general medicine and intensive care unit patients. " 03/01/2003 - "In our study, we found that quetiapine was a safe and effective treatment in hospitalized older patients with delirium." 10/01/2014 - "Quetiapine is regarded as an effective and safe treatment for delirium. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Olanzapine (Zyprexa)
3.	Risperidone (Risperdal Consta)
4.	Aripiprazole (Abilify)
5.	Quetiapine Fumarate (Seroquel)
6.	ziprasidone (Geodon)
7.	Clozapine (Clozaril)
8.	Lithium
9.	Haloperidol (Haldol)
10.	Valproic Acid (Depakote)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Secondary Prevention
4.	Drug Therapy (Chemotherapy)
5.	Injections