Type IV Secretion Systems

Multiprotein complexes that transport single proteins, multiprotein complexes, and nucleoprotein complexes from the CYTOPLASM into the EXTRACELLULAR SPACE or into recipient cells. T4SSs are found in GRAM-NEGATIVE BACTERIA, while homologous components to T4SSs are found in GRAM-POSTIVE BACTERIA.

Also Known As:

Networked: 200 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Haas, Rainer: 14 articles (01/2020 - 05/2005)
2.	Fischer, Wolfgang: 11 articles (01/2020 - 09/2007)
3.	Tsolis, Renée M: 10 articles (01/2019 - 09/2004)
4.	Peek, Richard M: 8 articles (01/2021 - 07/2005)
5.	Dehio, Christoph: 7 articles (01/2019 - 02/2002)
6.	Weiss, Evelyn: 6 articles (01/2018 - 09/2007)
7.	Hilbi, Hubert: 6 articles (02/2016 - 05/2006)
8.	Hansen, Lori M: 5 articles (12/2020 - 01/2012)
9.	Solnick, Jay V: 5 articles (12/2020 - 01/2012)
10.	Segal, Gil: 5 articles (01/2020 - 06/2004)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2014 - "However, the microorganism is no longer effective in eliciting in vitro host cell inflammation and apoptosis, possibly due to the non-functionality of the cag type IV secretion system. " 11/01/2020 - "Helicobacter pylori harbouring cag-pathogenicity island (cagPAI) which encodes type IV secretion system (T4SS) and cagA virulence gene are involved in inflammation of the gastric mucosa. " 01/01/2019 - "A major driver of this inflammation is a type IV secretion system (T4SS) encoded by the cag pathogenicity island (cagPAI), present in a subpopulation of more virulent H. " 05/01/2005 - "Unknown factors related to the type IV secretion system other than CagA may influence gastric inflammation." 01/01/2017 - "The human pathogen Helicobacter pylori uses the host receptor α5β1 integrin to trigger inflammation in host cells via its cag pathogenicity island (cag PAI) type IV secretion system (T4SS). "
2.	Infections 10/09/2023 - "Additionally, we emphasize the importance of further understanding the mechanism of type IV secretion, which will support us in combating antimicrobial resistance and treating type IV secretion system-related infections." 02/23/2023 - "Many Gram-negative pathogens rely on type IV secretion systems (T4SS) for infection. " 11/20/2022 - "BtpB is a Brucella type IV secretion system effector with a complex mechanism for manipulating host infection. " 11/16/2021 - "To better understand type IV secretion system regulation during infection, we examined transcriptomic data from active urethral infection samples from five men. " 11/16/2021 - "Transcriptional and Translational Responsiveness of the Neisseria gonorrhoeae Type IV Secretion System to Conditions of Host Infections."
3.	Ehrlichiosis 02/01/2023 - "Ehrlichia translocated factor-1 (Etf-1), a type IV secretion system effector, is essential for Ehrlichia infection of host cells. " 01/01/2021 - "Ehrlichia translocated factor-1 (Etf-1), a type IV secretion system (T4SS) effector, is a primary virulence factor for an obligatory intracellular bacterium, Ehrlichia chaffeensis In this study, we developed Etf-1-specific nanobodies (Nbs) by immunizing a llama to determine if intracellular Nbs block Etf-1 functions and Ehrlichia infection. "
4.	Stomach Neoplasms (Stomach Cancer) 08/01/2021 - "It is related to gastric cancer which can be injected into host cells via a type IV secretion system (T4SS). " 01/01/2020 - "The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). " 09/01/2001 - "Topics discussed comprise the signaling and the phenotypes associated with the type IV secretion system, the activation of target genes involved in gastric physiology, and putative mechanisms leading to the development of gastric cancer." 01/01/2018 - "Strains of Helicobacter pylori that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the cag pathogenicity island (cagPAI). " 01/01/2022 - "pylori strain-specific cag type IV secretion system (T4SS) augments gastric cancer risk and translocates DNA into epithelial cells where it activates the microbial DNA sensor TLR9 and suppresses injury in vivo; however, the ability of H. "
5.	Legionnaires' Disease (Legionnaire's Disease) 04/21/2023 - "In the process of infection, Legionella pneumophila secretes over 330 effectors into host cell via the Dot/Icm type IV secretion system to modulate multiple host cellular physiological processes, thereby changing the environment of the host cell and promoting the growth and propagation of the bacterium. " 01/01/2023 - "The amoeba-resistant bacterium Legionella pneumophila causes Legionnaires' disease and employs a type IV secretion system (T4SS) to replicate in the unique, ER-associated Legionella-containing vacuole (LCV). " 08/12/2014 - "Legionella pneumophila, the causative agent of Legionnaires' disease, uses the Dot/Icm type IV secretion system (T4SS) to translocate more than 300 effectors into host cells, where they subvert host cell signaling. " 09/01/2013 - "The causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS) to form in phagocytes a distinct "Legionella-containing vacuole" (LCV), which intercepts endosomal and secretory vesicle trafficking. " 08/01/2013 - "The genome of the Philadelphia-1 strain of Legionella pneumophila, the causative organism of Legionnaires' disease, encodes two virulence-associated type 4 secretion systems (T4SSs), the Dot/Icm type 4B (T4BSS) and the Lvh type 4A (T4ASS). "

Related Drugs and Biologics

1.	Virulence Factors (Pathogenicity Factors)
2.	Proteins (Proteins, Gene)
3.	Lipopolysaccharides
4.	Urease
5.	Membrane Proteins (Integral Membrane Proteins)
6.	Single-Domain Antibodies
7.	Staphylococcal Protein A (Protein A)
8.	Cytotoxins (Cytolysins)
9.	Oncogene Proteins (Oncogene Protein)
10.	DNA (Deoxyribonucleic Acid)