Mammary Analogue Secretory Carcinoma

A malignant neoplasm of epithelial cells of the SALIVARY GLANDS, with microcystic architecture, low-grade nuclei, and granular vacuolated cytoplasm.

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Acinar Cell Carcinoma
2.	Colorectal Neoplasms (Colorectal Cancer)
3.	Salivary Gland Neoplasms (Salivary Gland Cancer)
4.	Neoplasms (Cancer)
5.	Melanoma (Melanoma, Malignant)

Experts

1.	Ballout, Mohamad: 1 article (12/2021)
2.	Mckey, Remy: 1 article (12/2021)
3.	Saad, Wajih: 1 article (12/2021)
4.	Salame, Hassan: 1 article (12/2021)
5.	Florou, Vaia: 1 article (05/2021)
6.	Garrido-Laguna, Ignacio: 1 article (05/2021)
7.	Gilcrease, Glynn W: 1 article (05/2021)
8.	Maeda, Patricia: 1 article (05/2021)
9.	Nevala-Plagemann, Christopher: 1 article (05/2021)
10.	Whisenant, Jonathan: 1 article (05/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mammary Analogue Secretory Carcinoma:

1.	LipidsIBA 07/01/2015 - "Large lipid-rich mammary analogue secretory carcinoma of parotid gland: An unusual case." 10/01/2013 - "Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification."
2.	entrectinibIBA 01/01/2016 - "What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC)." 05/01/2021 - "Clinical Activity of Selitrectinib in a Patient With Mammary Analogue Secretory Carcinoma of the Parotid Gland With Secondary Resistance to Entrectinib."
3.	CateninsIBA 01/01/2014 - "Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes."
4.	STAT5 Transcription FactorIBA 10/01/2015 - "Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers."
5.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/01/2015 - "Mammary analogue secretory carcinoma (MASC) with an ETS variant gene 6 (ETV6)-neurotrophic tyrosine kinase receptor type 3 (NTRK3) translocation is a newly described type of salivary gland cancer. "
6.	Biomarkers (Surrogate Marker)IBA 01/01/2015 - "Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers."
7.	VimentinIBA 01/01/2014 - "Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. "
8.	S100 Proteins (S 100 Protein)IBA 01/01/2014 - "Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. "
9.	MucinsIBA 01/01/2014 - "One was reclassified as a mammary analogue secretory carcinoma, leaving four that fulfilled the criteria for signet ring cell adenocarcinoma: the presence of prominent signet ring or vacuolated cells arranged in islands, interconnecting strands, cords or sheets in a myxoid or hyaline stroma, or pools of mucin. "
10.	Perilipin-2IBA 10/01/2013 - "Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification."

Therapies and Procedures

1.	Adjuvant Radiotherapy 06/01/2016 - "Preservation of Facial Nerve With Adjuvant Radiotherapy for Recurrent Mammary Analogue Secretory Carcinoma of Parotid Gland."