Human Isophane Insulin

Human isophane insulin that is used to manage BLOOD GLUCOSE levels in patients with DIABETES.

Also Known As:

Isophane Insulin, Human; Humulin N; Insulatard; Insulin, NPH, Human; NPH Insulin, Human; Novolin N; Protophan; Protophane; Human NPH Insulin; Insulin, Human Isophane; Insulin, Human NPH; N, Humulin; N, Novolin

Networked: 33 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Riddle, Matthew C: 2 articles (01/2006 - 11/2003)
2.	Rosenstock, Julio: 2 articles (04/2005 - 11/2003)
3.	Berghold, Andrea: 1 article (11/2020)
4.	Engler, Jennifer: 1 article (11/2020)
5.	Horvath, Karl: 1 article (11/2020)
6.	Jeitler, Klaus: 1 article (11/2020)
7.	Semlitsch, Thomas: 1 article (11/2020)
8.	Siebenhofer, Andrea: 1 article (11/2020)
9.	Huang, Elbert S: 1 article (01/2018)
10.	Karter, Andrew J: 1 article (01/2018)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/01/1997 - "Twenty IDDM patients (age 19-55, duration 3-36 years) used Velosulin and Insulatard twice daily for 12 weeks, double-blinded to species (human (H) or porcine (P)) in a randomized crossover study. " 07/01/1987 - "A comparison of semisynthetic human NPH insulin and porcine NPH insulin in the treatment of insulin-dependent diabetes mellitus." 11/01/2005 - "This retrospective study demonstrated that using a mixture of different brands of insulin (Insulatard HM plus Humulin R) for 6 months did not change the efficacy of insulin in patients with type 1 diabetes mellitus." 09/01/2005 - "Three, up to 6 months trials, carried out in patients with type 1 diabetes have shown that the day-to-day within-subject variations in plasma glucose were significantly lower with insulin detemir than with human NPH insulin. " 10/01/2014 - "Therefore, we compared the GH-IGF1 axis response with human NPH insulin, insulin detemir, and insulin glargine in patients with type 1 diabetes (T1D). "
2.	Hypoglycemia (Reactive Hypoglycemia) 12/01/2001 - "A decreased incidence of hypoglycemia, particularly at night, has been reported with insulin glargine compared with human NPH insulin. " 01/01/2007 - "These results obtained from a larger number of patients as compared to previous Japanese studies confirm earlier reports that insulin glargine provides equivalent glycemic control to human NPH insulin, with a lower incidence of severe hypoglycemia. " 01/01/2018 - "To compare the rates of hypoglycemia-related emergency department (ED) visits or hospital admissions associated with initiation of long-acting insulin analogs vs human NPH insulin in patients with type 2 diabetes. " 04/01/2005 - "Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes." 10/01/2008 - "Nocturnal variations of EGP and Rd explain the reduced incidence of hypoglycemia and lower fasting glucose levels reported for insulin glargine compared with human NPH insulin."
3.	Type 2 Diabetes Mellitus (MODY) 02/01/2016 - "Comparative study between two recombinant human NPH insulin formulations for the treatment of type 2 diabetes mellitus." 11/01/2008 - "Thirty patients with type 2 diabetes mellitus who followed the human Isophane insulin therapeutic regimen at bedtime were given 100 g steamed bread tests in two consecutive days. " 05/01/1991 - "A 48-year-old man with non-insulin-dependent diabetes mellitus receiving biosynthetic isophane human insulin (Humulin N) developed itchy wheal-and-flare reactions at the sites of injection. " 01/01/2018 - "To compare the rates of hypoglycemia-related emergency department (ED) visits or hospital admissions associated with initiation of long-acting insulin analogs vs human NPH insulin in patients with type 2 diabetes. " 04/01/2005 - "Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes."
4.	Body Weight (Weight, Body) 03/01/2023 - "There is a positive correlation between doses of Regular insulin and Insulin human (Insulatard) with body weight and height. " 06/01/2003 - "This study set out to define relationships between changes in plasma leptin and changes in body weight, plasma insulin and blood glucose control during a 12-month crossover study of once-daily Ultratard or twice-daily Insulatard insulin. " 12/01/2012 - "The 2 separately analyzed experiments investigated the effects administering either Humulin N (H), a neutral protamine Hagedorn insulin, or insulin glargine (Lantus, L), an insulin analog, at doses of 0 (control), 0.1, 0.2, and 0.4 IU/kg of body weight in a randomized complete block design. " 11/01/2005 - "The average daily insulin requirement, hemoglobin A1c (HbA1c) level, body weight, and body mass index (BMI) were compared 6 months before (period 1, used same brand of insulin, Humulin N plus Humulin R) and after (period 2, used different brands of insulin, Insulatard HM plus Humulin R) the mixture treatment. "
5.	Diabetes Mellitus 01/01/2009 - "Neutral Protamine Hagedorn human analogue insulin (Humulin N) is commonly used for treatment of canine diabetes mellitus (DM). " 01/01/1997 - "The objectives of the study were to test the use of a prefilled insulin syringe (Insulatard Novolet, isophane insulin, 100 IU/mL) in treating diabetic dogs and to test the clinical usefulness of serum fructosamine measurements in diagnosing and monitoring diabetes mellitus in dogs. "

Related Drugs and Biologics

1.	Insulin Glargine (Lantus)
2.	Insulin (Novolin)
3.	Insulin Detemir (Levemir)
4.	Protamines (Protamine Sulfate)
5.	Glucose (Dextrose)
6.	Human Regular Insulin (Humulin)
7.	Isophane Insulin (NPH Insulin)
8.	Insulin Lispro (Humalog)
9.	Insulins
10.	Short-Acting Insulin

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Nutrition Therapy (Medical Nutrition Therapy)