ELAV-Like Protein 1
An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Also Known As:
ELAVL1 protein; HuR Antigen; HuR Paraneoplastic Encephalomyelitis Antigen; HuR Protein; Antigen, HuR; ELAV Like Protein 1; Protein, HuR; protein, ELAVL1
Networked: 82
relevant articles (1 outcomes,
6 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Ristimäki, Ari:
6 articles
(09/2016 - 11/2003)
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2. | Haglund, Caj:
5 articles
(09/2016 - 11/2003)
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3. | Wang, Jun:
4 articles
(01/2014 - 12/2007)
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4. | Denkert, Carsten:
4 articles
(02/2008 - 01/2004)
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5. | Dietel, Manfred:
4 articles
(02/2008 - 01/2004)
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6. | Weichert, Wilko:
4 articles
(02/2008 - 01/2004)
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7. | Wang, Baocheng:
3 articles
(01/2014 - 01/2009)
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8. | Niesporek, Silvia:
3 articles
(02/2008 - 08/2004)
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9. | Noske, Aurelia:
3 articles
(02/2008 - 08/2004)
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10. | Pergaris, Alexandros:
2 articles
(01/2022 - 01/2021)
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Related Diseases
1. | Pain (Aches)
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2. | Hypersensitivity (Allergy)
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3. | Neoplasms (Cancer)
05/27/2022
- " Herein, we review HuR protein structure, function, and its regulation, as well as its implications in the pathogenesis, progression, and treatment of hepatobiliary cancers. " 04/01/2021
- " HuR protein has been demonstrated to be an important regulatory factor in macrophage-mediated angiogenesis, a process in which macrophages are critical for tumor progression. " 01/01/2021
- " Because HuR functionality in cancer cells is dependent on HuR dimerization and its nuclear/cytoplasmic shuttling, we developed a new class of molecules targeting HuR protein dimerization. " 01/01/2019
- " For this reason, downregulation in HuR protein levels or inhibition of HuR biological function are, nowadays, attractive goals in cancer research. " 09/27/2016
- " Numerous cancers display increased HuR protein levels and its high cytoplasmic levels has been associated with a worse prognosis.In"
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4. | Breast Neoplasms (Breast Cancer)
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5. | Neoplasm Metastasis (Metastasis)
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Related Drugs and Biologics
Related Therapies and Procedures