RNAi Therapeutics

A form of disease treatment which involves the silencing of genes that are associated with a disease by the process of RNA INTERFERENCE.

Also Known As:

RNAi Therapy; RNAi-Based Therapeutics; RNAi-Based Therapy; RNAi Based Therapy; RNAi Therapies; RNAi-Based Therapies; Therapeutic, RNAi; Therapeutics, RNAi; Therapies, RNAi; Therapies, RNAi-Based; Therapy, RNAi; Therapy, RNAi-Based; RNAi Therapeutic

Networked: 318 relevant articles (23 outcomes, 51 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Biological Therapy: 6827
  - Genetic Therapy
    - RNAi Therapeutics: 318

Experts

1.	Fitzgerald, Kevin: 9 articles (01/2020 - 08/2008)
2.	Sweetser, Marianne T: 6 articles (01/2021 - 01/2018)
3.	Chen, Jihong: 6 articles (11/2020 - 09/2017)
4.	Adams, David: 6 articles (09/2020 - 08/2013)
5.	Coelho, Teresa: 6 articles (09/2020 - 08/2013)
6.	Farokhzad, Omid C: 5 articles (11/2021 - 01/2016)
7.	Tao, Wei: 5 articles (11/2021 - 12/2017)
8.	Kristen, Arnt V: 5 articles (09/2020 - 01/2018)
9.	Davidson, Beverly L: 5 articles (11/2016 - 01/2006)
10.	O'Driscoll, Caitriona M: 5 articles (11/2015 - 02/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Newly developed nonviral gene delivery approaches have shown improved anticancer efficacy suggesting that RNAi-based therapeutics provide novel opportunities to elicit significant gene silencing and induce regression of tumor growth. " 05/19/2009 - "Our work suggests that RNAi can alter immunity to targets and shows that not all tumor cells require direct RNAi exposure for treatment to be effective in vivo, pointing the way to a new class of RNAi-based therapy." 11/01/2023 - "Specifically, we outline different integrating and non-integrating viral platforms used for gene delivery, currently employed RNAi targets for anti-cancer effect, and various strategies used to optimize the safety and efficacy of these RNAi therapeutics. " 10/01/2023 - "In this review, challenges of delivering RNAi therapeutics to tumors and major organs are discussed, as well as their transition to clinical trials. " 12/28/2018 - "Recent developments in delivery technologies such nanoparticle carriers and conjugation strategies have allowed RNAi therapeutics to enter clinical trials in the treatment of cancer. "
2.	Virus Diseases (Viral Diseases) 10/05/2023 - "We discuss the principles of RNAi, its application in combating viral infections, and the current progress made in RNAi-based therapy for shrimp viral diseases. " 10/05/2023 - "This review paper provides an overview of RNAi-based therapy and its potential as a game-changer for shrimp viral diseases. " 10/05/2023 - "RNAi-Based Therapy: Combating Shrimp Viral Diseases." 10/01/2020 - "This review will summarise the current state of RNAi therapeutics for treating acute and chronic human virus infections. " 10/01/2012 - "RNA interference (RNAi) therapy, which silences expression of specific target genes, represents a promising approach for treating viral infections in mammalian hosts. "
3.	Leukemia 01/01/2017 - "Generating effective RNAi-based therapies with the potential to achieve leukemia remission remains critical unmet need. " 08/01/2019 - "Our study provides proof-of-principle that fusion oncogene specific RNAi therapeutics can be exploited against leukemic cells and promise novel treatment options for leukemia patients." 01/01/2017 - "The major concerns in this review include the approaches of the development of immuno-stimulatory gene transfer mediated-vaccination for leukemia therapy, RNAi-based therapy for leukemia and enhancement of sensitivity of target malignant cells to virotherapy and alteration of host immune response to favor oncolytic viruses. " 12/01/2014 - "We also describe a unique polypeptide-based nanoparticle formulation of CD22ΔE12-siRNA as an RNAi therapeutic candidate targeting CD22ΔE12 that is capable of delivering its siRNA cargo into the cytoplasm of leukemia cells causing effective CD22ΔE12 depletion and marked inhibition of leukemic cell growth. "
4.	Infections 06/01/2008 - "Employing Pol II-expressed pri-miR mimics may be useful in the treatment of HBV infection, and potentially also for generic application in RNAi-based therapy." 04/23/2021 - "Our study could benefit the investigation of the specific functions of viral genes related to PDCoV infection and offer a possible methodology of RNAi-based therapeutics for PDCoV infection." 12/01/2021 - "Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection." 11/15/2016 - "ceranae and improve the overall health of honey bees, which highlights the potential role of host-derived and RNAi-based therapeutics in controlling the infections in honey bees. " 09/01/2014 - "We have focused our discussion on the current state-of-the-art RNAi-based therapies, which have been explored for various intracellular infections mediated by bacteria, fungi, viruses and protozoa. "
5.	Liver Diseases (Liver Disease) 01/01/2020 - "RNAi therapy holds promise for the treatment of patients with AATD-associated liver disease. " 01/01/2022 - "RNAi-based therapeutics is revolutionizing the treatment of liver diseases, with recent chemical advances supporting long-term gene silencing with single subcutaneous administration. " 01/01/2020 - "Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease." 01/01/2018 - "RNAi-based therapeutics silencing production of hepatic Z-AAT might benefit patients with AATD-associated liver disease. " 01/01/2017 - "To date, RNAi therapeutics have advanced into clinical trials for liver diseases and solid tumors; however, delivery of RNAi to leukocytes in general and to lymphocytes in particular remains a challenge. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	RNA (Ribonucleic Acid)
3.	Enzymes
4.	patisiran
5.	Prealbumin (Transthyretin)
6.	givosiran
7.	Polyethyleneimine
8.	Lipids
9.	MicroRNAs (MicroRNA)
10.	lumasiran

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	RNAi Therapeutics
4.	Topical Administration
5.	Radiotherapy