2,3,5- trichloro- 6- phenyl- (1,4)benzoquinone

02/01/2020 - "In short, our study uncovered that PCB29-pQ could promote macrophage/monocyte polarization to CD163+ macrophage which would be a potential incentive to accelerate atherosclerosis through Nrf2 signaling pathway."
01/01/2020 - "Overall, PCB29-pQ exposure resulted in lipid accumulation, ER stress response, apoptosis, and pro-inflammatory cytokines release via CD36, ultimately leading to atherosclerosis."
01/01/2022 - "We used human umbilical vein endothelial cells (HUVECs) and apolipoprotein E knockout (ApoE-/-) mice to investigate how 2,3,5-trichloro-6-phenyl-[1,4]-benzoquinone (PCB29-pQ, a toxic polychlorinated biphenyl metabolite) affects atherogenesis and identified early biomarkers of CVD associated with PCB29-pQ exposures. "

01/01/2022 - "Overall, our results demonstrated a novel mechanism that PCB29-pQ exposure promotes aerobic glycolysis in both in vitro and in vivo breast cancer models in a GLUT1-dependent fashion, which may provide a strategy to prevent breast cancer cell spread."
01/01/2018 - "Multiple lines of evidence illustrated that PCB29-pQ induces breast cancer invasion and migration. "
01/01/2021 - "Here, our data illustrate that PCB29-pQ increases cancer stem cell (CSC) marker expression, resulting in an increase in the epithelial-mesenchymal transition (EMT) in MDA-MB-231 breast cancer cells; further, the Wnt/β-catenin pathway also becomes activated by PCB29-pQ. "
01/01/2018 - "Collectively, our result suggested that PCB29-pQ induces breast cancer metastasis via ROS-dependent NF-κB-MMP signaling."
01/01/2022 - "PCB29-pQ exposure activated corresponding glucose transporter type 1 (GLUT1)/integrin β1/Src/focal adhesion kinase (FAK) signaling pathway in breast cancer MDA-MB-231 cells. "

12/16/2019 - "Overall, our results indicated that PCB29-pQ promoted the macrophage formation of foam cells, inflammation, and cell necroptosis."
01/01/2023 - "Phosphorylated proteomics analysis indicated that PCB29-pQ treatment significantly enriched phosphorylated peptides in protein binding functions, inflammation, and apoptosis signaling. "

06/10/2022 - "After PCB29-pQ exposure, the body weight of the mice was reduced, but increased the organ index of the spleen and lungs. "
01/01/2020 - "Aortic plaques were increased in PCB29-pQ-treated ApoE-/- mice [intraperitoneally (i.p.) injection of 5 mg/kg body weight of PCB29-pQ once a week for 12 continuous weeks, high-fat feeding]. "

01/01/2023 - "Meanwhile, apolipoprotein E knockout (ApoE-/-) mice exposed to PCB29-pQ had increased atherosclerotic plaques compared to the vehicle group, while this effect was significantly reduced in ApoE-/-/CAV1-/- double knockout mice. "