Jiedu Xiaozheng Yin

contains: Hedyotis Diffusa Willd (HDW), Sophora flavescens (SF), Psuedobulbus Cremastrae (PC), Prunella Bidens and Ban Zhi Lian; BRM270 is the ethyl acetate extract of Jiedu Xiaozheng Yin and has antineoplastic and NF-kappaB inhibitory activities

Also Known As:

Networked: 16 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Park, Yang Ho: 8 articles (10/2020 - 01/2015)
2.	Jeong, Dong Kee: 7 articles (04/2019 - 01/2015)
3.	Kim, Nameun: 7 articles (04/2019 - 01/2015)
4.	Chandimali, Nisansala: 6 articles (10/2020 - 01/2018)
5.	Kwon, Taeho: 6 articles (10/2020 - 01/2018)
6.	Ghosh, Mrinmoy: 6 articles (04/2019 - 01/2015)
7.	Huynh, Do Luong: 6 articles (04/2019 - 01/2016)
8.	Du, Jian: 5 articles (02/2017 - 01/2013)
9.	Sharma, Neelesh: 4 articles (04/2019 - 01/2015)
10.	Zhang, Jiao Jiao: 4 articles (04/2019 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2017 - "BRM270 is a proprietary combination of traditional medicinal herbs, has been shown to be effective against a wide range of stem-like cancer initiating cells (SLCICs). " 01/01/2015 - "The aim of this study was to investigate the selective and potential efficacy of BRM270 against stem-like cancer-initiating cells (SLCICs) via the molecular mechanisms of its anticancer effects. " 09/24/2021 - "Endostatin + BRM270 showed anti-tumor effects by reducing tumor volume and increasing survival. " 10/01/2020 - "The present review discusses the effects of BRM270 treatment against CSC-associated chemoresistance in common types of cancer." 10/01/2020 - "BRM270 targets cancer stem cells and augments chemo-sensitivity in cancer."
2.	Hepatocellular Carcinoma (Hepatoma) 03/01/2017 - "However, the underlying mechanism and antitumor efficacy of BRM270 in human hepatocellular carcinoma (HCC) cells have not been well elucidated till date. " 02/01/2017 - "In the present study, we evaluated the synergistic effect of APRIL knockdown and Jiedu Xiaozheng Yin (JXY), a Traditional Chinese Medicinal recipe, on the inhibition of hepatocellular carcinoma (HCC) cell proliferation and elucidated the underlying mechanism. " 03/01/2017 - "In conclusion, these results indicate that BRM270 can effectively inhibit proliferation and induce apoptosis in hepatoma cells by down-regulating CyclinD1/Bcl2 mediated c-Jun apoptotic pathway." 03/01/2017 - "Novel phyto-derivative BRM270 inhibits hepatocellular carcinoma cells proliferation by inducing G2/M phase cell cycle arrest and apoptosis in xenograft mice model." 02/01/2017 - "Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation."
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 05/01/2020 - "BRM270 might be an effective agent for cervical cancer treatment." 05/01/2020 - "SOX2-expressing SiHa and C33A cell lines were selected for further experiments on the in vitro and in vivo effects of BRM270 on cervical cancer progression using western blotting, flow cytometry, sphere-formation assay, magnetic-activated cell sorting of CD133+ cervical cancer cells, and xenografts in female athymic BALB/c nude mice. " 05/01/2020 - "BRM270 Suppresses Cervical Cancer Stem Cell Characteristics and Progression by Inhibiting SOX2." 05/01/2020 - "In the present study, in cervical cancer stem cells (CSCs), we found that BRM270 inhibited expression of SOX2, which is associated with cervical cancer initiation and metastasis. " 05/01/2020 - "This study was designed to evaluate the therapeutic effects of plant extract formulation BRM270 against cervical cancer progression. "
4.	Carcinogenesis 01/01/2018 - "We previously demonstrated that BRM270 suppresses tumorigenesis by negatively regulating nuclear factor-κB signaling in multidrug-resistant cancer stem cells (CSCs). " 01/01/2019 - "In vivo study indicated that tumor growth derived from CD44+ PDAC was suppressed as daily uptake by BRM270 5 mg/kg. These data suggest the alternative approach in antipancreatic tumorigenesis via herbal plants extract and selectively targeting CD44+ PDAC cells in tumor." 01/01/2015 - "The novel inhibitor BRM270 downregulates tumorigenesis by suppression of NF-κB signaling cascade in MDR-induced stem like cancer-initiating cells." 01/01/2016 - "Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma."
5.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "Moreover, BRM270 also inhibits stemness and metastasis traits in CD44+ PDAC via Sonic hedgehog signaling pathway and SALL4 expression. " 05/01/2020 - "In the present study, in cervical cancer stem cells (CSCs), we found that BRM270 inhibited expression of SOX2, which is associated with cervical cancer initiation and metastasis. " 01/01/2016 - "Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma." 01/01/2016 - "Our results also illustrate a molecular mechanistic approach for 2DG-guided molecular imaging-based cancer therapy using BRM270 as a novel cancer therapeutic drug to enhance the effect of doxorubicin (Dox)-resistant LCN2 induced metastasis of solid tumors in nude mice. " 01/01/2015 - "BRM270 directly dephosphorylated RelA and selectively inhibited NF-κB transcriptional activity, resulting in decreased expression of interleukin-6, a cytokine implicated in cancer metastasis. "

Related Drugs and Biologics

1.	Plant Extracts
2.	Therapeutic Uses
3.	Endostatins
4.	Paclitaxel (Taxol)
5.	Gefitinib (Iressa)
6.	ethyl acetate
7.	Catenins
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
10.	MicroRNAs (MicroRNA)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Chemoradiotherapy
3.	Therapeutics