valienone

isolated from Streptomyces sp.; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/08/2019 - "The aminotransferase from Bacillus circulans (BtrR), which is involved in the biosynthesis of butirosin, catalyzes the pyridoxal phosphate (PLP)-dependent transamination reaction to convert valienone to β-valienamine (a new β-glycosidase inhibitor for the treatment of lysosomal storage diseases) with an optical purity enantiomeric excess value. "
2.	Dehydration (Water Stress) 07/27/2001 - "To probe the dehydration mechanism of 5-epi-valiolone to valienone, stereospecifically 6alpha- and 6beta-monodeuterated 5-epi-valiolones were synthesized. " 07/27/2001 - "Incorporation experiments with the labeled precursors in the validamycin A producer strain, Streptomyces hygroscopicus var. limoneus, revealed that the dehydration of 5-epi-valiolone to valienone occurs by a syn elimination of water."

1.	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)
2.	Glycoside Hydrolases (Endoglycosidases)
3.	Butirosin Sulfate (Butirosin)
4.	Transaminases (Aminotransferases)
5.	5-epi-(6-(2)H2)valiolone
6.	valienamine
7.	validamycin A