4,4'-hexafluorisopropylidene diphenol

Also Known As:

2,2-Bis(4-hydroxyphenyl)perfluoropropane; 2,2-bis(4-hydroxyphenyl)hexafluoropropane; 4,4'-(hexafluoroisopropylidene)diphenol; BPAF compound; Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-; bisphenol AF

Networked: 26 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzhydryl Compounds
        4,4'-hexafluorisopropylidene diphenol: 26
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorocarbons: 1209
        4,4'-hexafluorisopropylidene diphenol: 26

Experts

1.	Chen, Zhihong: 3 articles (04/2022 - 09/2021)
2.	Liu, Yungang: 3 articles (04/2022 - 09/2021)
3.	Yang, Zongying: 3 articles (04/2022 - 09/2021)
4.	Yu, Hang: 3 articles (04/2022 - 09/2021)
5.	Hu, Keqi: 2 articles (04/2022 - 09/2021)
6.	Aramaki, Hironori: 2 articles (01/2018 - 01/2017)
7.	Haraguchi, Koichi: 2 articles (01/2018 - 01/2017)
8.	Okazaki, Hiroyuki: 2 articles (01/2018 - 01/2017)
9.	Takeda, Shuso: 2 articles (01/2018 - 01/2017)
10.	Watanabe, Kazuhito: 2 articles (01/2018 - 01/2017)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Bisphenol AF-induced endogenous transcription is mediated by ERα and ERK1/2 activation in human breast cancer cells." 01/01/2018 - "Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines." 12/02/2015 - "Bisphenol AF (4,4'-hexafluoroisopropylidene-2-diphenol, BPAF), an endocrine disruptor, has been shown to stimulate the proliferation of human breast cancer cells. " 01/01/2017 - "Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells." 12/02/2015 - "Bisphenol AF stimulates transcription and secretion of C-X-C chemokine ligand 12 to promote proliferation of cultured T47D breast cancer cells."
2.	Neoplasms (Cancer) 11/26/2022 - "Bisphenol AF Promoted the Growth of Uterus and Activated Estrogen Signaling Related Targets in Various Tissues of Nude Mice with SK-BR-3 Xenograft Tumor." 03/01/2019 - "A significant relationship was found between malignancy and the detection in the serum of both bisphenol AF and DEHP. " 07/15/2014 - "Bisphenol AF (BPAF) is an environmental pollutant to disrupt endocrine system or cause cancer, thus the detection of trace BPAF is very important. " 06/01/2018 - "Because bisphenol A (BPA) and some of its analogs have been supposed to influence development of cancer, we have assessed the effect of BPA, bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF) on DNA bases oxidation, which is a key process in cancer initiation. " 11/26/2022 - "Therefore, the present study investigated the effects of environmental estrogen bisphenol AF (BPAF) on the main organs of female Balb/cA nude mice with SK-BR-3 xenograft tumor by detecting the organ development and gene expression of targets associated with G protein-coupled estrogen receptor 1 (GPER1)-mediated phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase (MAPK) signaling pathways in hypothalamus, ovary, uterus, liver, and kidney. "
3.	Cardiotoxicity 01/01/2020 - "Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/eNOS pathway." 08/20/2020 - "Oxidative stress in bisphenol AF-induced cardiotoxicity in zebrafish and the protective role of N-acetyl N-cysteine."
4.	Endometriosis 12/01/2018 - "The objective of this study was to determine if bisphenol A (BPA) or bisphenol AF (BPAF) potentiate the development of endometriosis and if hormonal status alters how toxicant exposure affects disease. " 12/01/2018 - "Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure."
5.	Hepatocellular Carcinoma (Hepatoma) 04/15/2022 - "Influence of aryl hydrocarbon receptor and sulfotransferase 1A1 on bisphenol AF-induced clastogenesis in human hepatoma cells." 09/15/2021 - "In a human hepatoma (HepG2) cell line, EHDPP (48 h exposure) moderately induced micronuclei, which was blocked by 1-aminobenzotriazole (ABT, 60 μM, inhibitor of CYPs); pretreating HepG2 cells with bisphenol AF, another organic pollutant as inducer of CYPs (0.1 μM for 16 h), significantly potentiated micronuclei formation by EHDPP, threshold being decreased from 10 to 1.25 μM. " 10/15/2019 - "Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells." 03/01/2022 - "In the human hepatoma (HepG2) cells BDE-47 (48 h exposure) was inactive up to 40 μM, however, pretreatment of the cells with ethanol (0.2%, v:v, inducer of CYP2E1) or rifampicin (10 μM, inducer of CYP3A4) led to significant micronuclei formation by BDE-47; pretreatment with bisphenol AF (100 nM) also potentiated BDE-47-induced micronuclei formation (which was blocked by a CYP2E1 inhibitor trans-1,2-dichloroethylene or a CYP3A inhibitor (ketoconazole). "

Related Drugs and Biologics

1.	bisphenol A
2.	Estrogens (Estrogen)
3.	bis(4-hydroxyphenyl)sulfone
4.	bisphenol B
5.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
6.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
7.	Estrogen Receptor alpha
8.	Mitogen-Activated Protein Kinases
9.	GTP-Binding Proteins (G-Protein)
10.	bisphenol F