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3- (4- (benzo(d)(1,3)dioxol- 5- yl)- 2- oxobut- 3- en- 1- ylidene)indolin- 2- one

an aurora B kinase inhibitor; structure in first source

Also Known As:

HOI-07

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - 3-(4-(benzo(d)(1,3)dioxol-5-yl)-2-oxobut-3-en-1-ylidene)indolin-2-one: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 3-(4-(benzo(d)(1,3)dioxol-5-yl)-2-oxobut-3-en-1-ylidene)indolin-2-one: 2
    - Benzodioxoles: 3
      - 3-(4-(benzo(d)(1,3)dioxol-5-yl)-2-oxobut-3-en-1-ylidene)indolin-2-one: 2

Experts

1.	Bode, Ann M: 2 articles (01/2019 - 01/2013)
2.	Dong, Zigang: 2 articles (01/2019 - 01/2013)
3.	Reddy, Kanamata: 2 articles (01/2019 - 01/2013)
4.	Chen, Hanyong: 1 article (01/2019)
5.	Gorja, Dhilli Rao: 1 article (01/2019)
6.	Guo, Zhiping: 1 article (01/2019)
7.	Jin, Guoguo: 1 article (01/2019)
8.	Liu, Fangfang: 1 article (01/2019)
9.	Liu, Kangdong: 1 article (01/2019)
10.	Wang, Keke: 1 article (01/2019)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2019 - "Results of a xenograft mouse study indicated that HOI-07 treatment effectively suppressed the growth of 143B and KHOS xenografts, without affecting the body weight of mice. " 01/15/2013 - "Results of an in vivo xenograft mouse study showed that HOI-07 treatment effectively suppressed the growth of A549 xenografts, without affecting the body weight of mice. "
2.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2019 - "Moreover, knocking down the expression of Aurora B effectively reduced the sensitivity of osteosarcoma to HOI-07. " 01/01/2019 - "We developed a compound, HOI-07 (i.e., (E)-3-((E)-4-(benzo[d] [1,3]dioxol-5-yl)-2-oxobut-3-en-1-ylidene)indolin-2-one), as a specific Aurora B kinase inhibitor and examined its effectiveness against osteosarcoma cell growth in this study. " 01/01/2019 - "Overall, we identified HOI-07 as a specific Aurora B kinase inhibitor for osteosarcoma treatment and this compound warrants further investigation."
3.	Neoplasms (Cancer) 01/15/2013 - "Moreover, knocking down the expression of Aurora B effectively reduced the sensitivity of cancer cells to HOI-07. "

Related Drugs and Biologics

1.	Aurora Kinase B