4- oxo- 6- ((pyrimidin- 2- ylthio)methyl)- 4H- pyran- 3- yl 4-nitrobenzoate

05/15/2023 - "This study aimed to investigate the effects of APJ antagonist ML221 in combination with a DC vaccine on angiogenic, metastatic and apoptotic-related factors in a breast cancer (BC) model. "
03/01/2022 - "Here, we investigated the efficacy of a dendritic cell (DC) vaccine in combination with an apelin receptor antagonist, ML221, to modulate Th1 and Th2 cell-related responses in breast cancer-bearing mice. "

01/01/2017 - "ML221 treatment significantly decreased tumor growth in nu/nu mice. "
01/01/2019 - "Using various ovarian cancer model systems, we demonstrate that APJ expression in cancer cells is both necessary and sufficient to increase prometastatic phenotypes in vitro, including proliferation, cell adhesion to various molecules of the extracellular matrix (ECM), anoikis resistance, migration, and invasion; and these phenotypes are efficiently inhibited by the APJ inhibitor, ML221. "
03/01/2022 - "Tumor-bearing mice were then given PBS, ML221, DC vaccine and "ML221 + DC vaccine" for 21 days. "
03/01/2022 - "Combination therapy with ML221 + DC vaccination was more effective in reducing tumor growth (P ​< ​0.0001), preventing lung metastasis (P ​< ​0.0001) and increasing survival rate (P ​< ​0.01) compared to the control group. "
03/01/2022 - "Our findings showed that combination therapy using ML221 + DC vaccine can be considered as an effective cancer therapeutic program to potentiate anti-tumor immune responses."

03/01/2022 - "Combination therapy with ML221 + DC vaccination was more effective in reducing tumor growth (P ​< ​0.0001), preventing lung metastasis (P ​< ​0.0001) and increasing survival rate (P ​< ​0.01) compared to the control group. "

08/01/2017 - "The present study demonstrated that a single application of ML221 alleviated mechanical allodynia and heat hyperalgesia 7 days following CCI, in a dose‑dependent manner. "

10/30/2021 - "Chronic intermittent hypoxia (CIH) rat model was established to induce the environment of renal fibrosis and a competitive antagonist of the APJ receptor ML221 was administered to CIH rats. "
01/01/2021 - "ML221 treatment or APLN-/- reduced BDL-induced and Mdr2-/- -induced cholangiocyte proliferation/senescence, liver inflammation, fibrosis, and angiogenesis. "
10/30/2021 - "However, the degree of renal fibrosis in ML221 group was further significantly increased after inhibiting the expression of Apelin. "
10/30/2021 - "At the cellular level, CIH model cells treated with Apelin-13 significantly reduced cell proliferation, oxidative stress and inflammatory response, and decreased the expression of fibrosis-related proteins, which can be reversed by ML221 administration. "