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indimitecan

structure in first source

Also Known As:

LMP776

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - indimitecan: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - indimitecan: 6
    - Benzodioxoles: 3
      - indimitecan: 6

Experts

1.	Pommier, Yves: 6 articles (01/2020 - 12/2012)
2.	Difilippantonio, Simone: 2 articles (01/2020 - 01/2018)
3.	James, Amy: 2 articles (01/2020 - 01/2018)
4.	Marzi, Laetitia: 2 articles (01/2020 - 01/2018)
5.	Agama, Keli: 2 articles (01/2018 - 12/2012)
6.	Cushman, Mark: 2 articles (01/2018 - 12/2012)
7.	Bièche, Ivan: 1 article (01/2020)
8.	Briaux, Adrien: 1 article (01/2020)
9.	Château-Joubert, Sophie: 1 article (01/2020)
10.	Coussy, Florence: 1 article (01/2020)

Related Diseases

1.	Lymphoma (Lymphomas) 12/01/2018 - "Three indenoisoquinolines, LMP400 (indotecan), LMP776 (indimitecan), and LMP744, were examined in a phase I study for lymphoma-bearing dogs to evaluate differential efficacy, pharmacodynamics, toxicology, and pharmacokinetics. "
2.	Neoplasms (Cancer) 12/27/2012 - "The hydroxylated indotecan and indimitecan metabolites and analogues were tested as Top1 poisons and for antiproliferative activity in a variety of human cancer cell cultures and in general were found to be very potent. " 11/15/2019 - "We introduce new therapeutic strategies based on novel TOP1 inhibitor chemical scaffolds including the indenoisoquinolines LMP400 (indotecan), LMP776 (indimitecan), and LMP744, and on tumor-targeted delivery TOP1 inhibitors using liposome, PEGylation, and antibody-drug conjugates. " 12/27/2012 - "Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons."
3.	Leukemia 01/01/2018 - "We tested the induction and stability of TOP1 cleavage complexes (TOP1cc), and the induction and persistence of DNA damage measured by histone H2AX phosphorylation (γH2AX) compared with their parent compounds LMP744 and LMP776 in leukemia CCRF-CEM and colon carcinoma HCT116 cells. "
4.	Diarrhea 01/01/2020 - "Because of the chemical instability of camptothecins, short plasma half-life, drug efflux by the multidrug-resistance ABC transporters, and the severe diarrhea produced by irinotecan, indenoisoquinoline TOP1 inhibitors (LMP400, LMP776, and LMP744), which overcome these limitations, have been developed and are in clinical development. "
5.	Carcinoma (Carcinomatosis) 01/01/2018 - "We tested the induction and stability of TOP1 cleavage complexes (TOP1cc), and the induction and persistence of DNA damage measured by histone H2AX phosphorylation (γH2AX) compared with their parent compounds LMP744 and LMP776 in leukemia CCRF-CEM and colon carcinoma HCT116 cells. "

Related Drugs and Biologics

1.	indimitecan
2.	NSC 724998
3.	Irinotecan (Camptosar)
4.	Immunoconjugates (Immunoconjugate)
5.	ATP-Binding Cassette Transporters (ABC Transporters)
6.	Proteins (Proteins, Gene)
7.	Poisons
8.	Liposomes (Liposome)
9.	Histones (Histone)
10.	Type I DNA Topoisomerases (Topoisomerase I)