platyconic acid

from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo; structure in first source

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

1.	Insulinoma 08/01/2012 - "Platyconic acid (PA) most effectively increased insulin-stimulated glucose uptake in 3T3-L1 adipocytes, possibly in part by working as a peroxisome proliferator-activated receptors (PPAR)-γ activator; however, none of the saponins improved glucose-stimulated insulin secretion in insulinoma cells. "
2.	Ischemia 07/07/2009 - "In this study, we investigated the neuroprotective effects of five major extracts; deapioplatycoside E (DPE), platycoside E (PE), platyconic acid A (PA), platycodin D (PD) and 2''-o-acetyl-polygalacin D2 (PD2) isolated from the P.radix in the hippocampal CA1 region (CA1) 4 or 10 days after ischemia/reperfusion (I/R). "
3.	Inflammation (Inflammations) 11/01/2022 - "Platyconic acid A‑induced PPM1A upregulation inhibits the proliferation, inflammation and extracellular matrix deposition of TGF‑β1‑induced lung fibroblasts." 02/11/2015 - "Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells."
4.	Liver Cirrhosis (Hepatic Cirrhosis) 11/01/2022 - "Platyconic acid A (PA), the active component of Platycodi radix‑derived saponin, exerts ameliorating effects on liver fibrosis. "
5.	Insulin Resistance 08/01/2012 - "Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo."

1.	Saponins
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Neuroprotective Agents
6.	2''-O-acetyl-polygalacin D2
7.	platycoside E
8.	platycodin D
9.	Ovalbumin