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4- (4- (4- chlorophenyl)- 1,4- diazepan- 1- yl)- 1- (4- fluorophenyl)butan- 1- one

an antipsychotic agent; structure in first source

Also Known As:

SYA013

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one: 2
Organic Chemicals: 133
- Ketones: 2618
  - Butyrophenones: 43
    - Haloperidol: 5363
      - 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one: 2

Experts

1.	Ablordeppey, Seth Y: 2 articles (12/2020 - 08/2012)
2.	Amissah, Felix: 1 article (12/2020)
3.	Asong, Gladys M: 1 article (12/2020)
4.	Lamango, Nazarius S: 1 article (12/2020)
5.	Nkembo, Augustine T: 1 article (12/2020)
6.	Ntantie, Elizabeth: 1 article (12/2020)
7.	Voshavar, Chandrashekhar: 1 article (12/2020)
8.	Boateng, Bernard: 1 article (08/2012)
9.	Bricker, Barbara: 1 article (08/2012)
10.	Jackson, Tanise: 1 article (08/2012)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 08/01/2012 - "Previously, SYA013 was tested in mice with an antipsychotic screening model in which it inhibited apomorphine induced climbing behavior, indicating antagonism of the dopaminergic system and the potential for use in the treatment of schizophrenia. " 12/29/2020 - "We have previously reported that certain analogues of haloperidol (a typical antipsychotic drug used for treating mental/mood disorders such as schizophrenia and bipolar disorder) suppress the viability of a variety of solid tumor cell lines, and we have identified 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluoro-phenyl)butan-1-one (SYA013) with such antiproliferative properties. "
2.	Triple Negative Breast Neoplasms 12/29/2020 - "A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells."
3.	Mood Disorders (Mood Disorder) 12/29/2020 - "We have previously reported that certain analogues of haloperidol (a typical antipsychotic drug used for treating mental/mood disorders such as schizophrenia and bipolar disorder) suppress the viability of a variety of solid tumor cell lines, and we have identified 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluoro-phenyl)butan-1-one (SYA013) with such antiproliferative properties. "
4.	Neoplasms (Cancer) 12/29/2020 - "In addition, we have demonstrated that SYA013 induces MDA-MB-231 cell death through the intrinsic apoptotic pathway and may suppress tumor progression and metastasis. "
5.	Neoplasm Metastasis (Metastasis) 12/29/2020 - "In addition, we have demonstrated that SYA013 induces MDA-MB-231 cell death through the intrinsic apoptotic pathway and may suppress tumor progression and metastasis. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Haloperidol (Haldol)
3.	Apomorphine
4.	N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamide