28-hydroxy-3-oxo-12-ursene

12/28/2009 - "In summary, these studies demonstrated that waltonitone might inhibit hepatocellular carcinoma cells growth and induce apoptosis in vitro and in vivo."
12/28/2009 - "Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo."
12/01/2009 - "To investigate effects of Akt and ERK1/2 signaling pathways on waltonitone (WT) induced cell growth inhibition in human hepatocellular carcinoma BEL-7402 cells. "
11/15/2016 - "Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway."
12/28/2009 - "Waltonitone, a new ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill significantly inhibited human hepatocellular carcinoma BEL-7402 cells growth. "

02/01/2015 - "In summary, the present study demonstrated that waltonitone induced apoptosis of lung cancer cells through, at least partly, miR-663-induced Bcl-2 downregulation. "
02/01/2015 - "In the present study, we treated H460 and H3255 lung cancer cells using different concentration of waltonitone (0, 10, 20, 30 μmol/L). "
02/01/2015 - "Our previous study reported that waltonitone treatment inhibited proliferation and induced apoptosis of lung cancer cells. "
09/01/2012 - "Suppression of growth of A549 lung cancer cells by waltonitone and its mechanisms of action."

02/01/2015 - "We also observed upregulation of miR-663, a potential tumor suppressor, after waltonitone treatment. "
12/28/2009 - "Meanwhile, the inhibitory effect of waltonitone was examined in vivo using BEL-7402 tumor cells xenografted into athymic mice model. "
12/28/2009 - "RT-PCR and Western blotting analysis showed that waltonitone could induce tumor cell apoptosis via both death receptor and mitochondria pathways. "
11/15/2016 - "Waltonitone (WA), an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, was recently appeared to exert anti-tumor effect. "

11/15/2016 - "Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway."

02/01/2015 - "Waltonitone induces apoptosis through mir-663-induced Bcl-2 downregulation in non-small cell lung cancer."