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HS-116

structure in first source

Also Known As:

N-(5-(3-(3-cyanophenyl)-1H-pyrrolo(2,3-b)pyridin-5-yl)pyridin-3-yl)benzenesulfonamide

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Choi, Myung-Joo: 1 article (03/2012)
2.	Hong, Sang-Won: 1 article (03/2012)
3.	Hong, Seunghee: 1 article (03/2012)
4.	Hong, Soon-Sun: 1 article (03/2012)
5.	Hong, Sungwoo: 1 article (03/2012)
6.	Jung, Kyung Hee: 1 article (03/2012)
7.	Lee, Hee-Seung: 1 article (03/2012)
8.	Lee, Hyunseung: 1 article (03/2012)
9.	Zheng, Hong-Mei: 1 article (03/2012)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 03/28/2012 - "This study aimed to clarify the anticancer effect of HS-116 in human hepatocellular carcinoma (HCC). " 03/28/2012 - "HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway."
2.	Neoplasms (Cancer) 03/28/2012 - "As PI3K is active in many cancer patients, resulting in cancer development and progression, we developed an azaindole derivative, HS-116 as a novel PI3K inhibitor. "
3.	Hypoxia (Hypoxemia) 03/28/2012 - "Furthermore, HS-116 decreased protein expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF), and inhibited the tube formation and migration of human umbilical vein endothelial cells (HUVECs). "

Related Drugs and Biologics

1.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Proteins (Proteins, Gene)