25-methoxyhispidol A

from Poncirus trifoliata; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Retinoblastoma (Glioblastoma, Retinal) 02/01/2008 - "Further study revealed that the cell cycle arrest in the G1 phase by 25-methoxyhispidol A correlated well with the inhibition of phosphorylation of the retinoblastoma (Rb) protein, and with the down-regulation of cyclin D1 and cyclin-dependent kinase cdk4 and the induction of cdk inhibitor p21 (WAF1/Cip1) protein. "
2.	Neoplasms (Cancer) 02/01/2008 - "Flow cytometric analysis indicated that 25-methoxyhispidol A arrests the cell cycle in the G1 phase at the earlier time and subsequently induces apoptosis of the cancer cells. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/01/2008 - "Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells."
4.	Breast Neoplasms (Breast Cancer) 11/01/2011 - "25-Methoxyhispidol A, a novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR/c-Src signaling pathway in MDA-MB-231 human breast cancer cells."