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decahydrodecaborate

used in boron neutron capture therapy

Also Known As:

GB 10 compound; GB-10 compound

Networked: 9 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Garabalino, Marcela A: 5 articles (01/2019 - 08/2013)
2.	Schwint, Amanda E: 5 articles (01/2019 - 08/2013)
3.	Trivillin, Verónica A: 4 articles (01/2019 - 08/2013)
4.	Monti Hughes, Andrea: 3 articles (01/2019 - 08/2013)
5.	Nigg, David W: 3 articles (01/2019 - 08/2013)
6.	Pozzi, Emiliano C C: 3 articles (01/2019 - 08/2013)
7.	Aromando, Romina F: 2 articles (01/2019 - 08/2013)
8.	Curotto, Paula: 2 articles (01/2019 - 04/2015)
9.	González, Sara J: 2 articles (01/2019 - 08/2013)
10.	Hughes, Andrea Monti: 2 articles (01/2019 - 11/2016)

Related Diseases

1.	Mouth Neoplasms (Oral Cancer) 04/01/2015 - "We previously reported the therapeutic efficacy of Sequential Boron Neutron Capture Therapy (Seq-BNCT), i.e., BPA (boronophenylalanine) - BNCT followed by GB-10 (decahydrodecaborate) - BNCT 1 or 2 days later, in the hamster cheek pouch oral cancer model. " 01/01/2023 - "We previously demonstrated the optimization of boron biodistribution and microdistribution employing electroporation (EP) and decahydrodecaborate (GB-10) as the boron carrier in a hamster cheek pouch oral cancer model. " 01/01/2019 - "We performed biodistribution studies and qualitative microdistribution analyses of boron employing the boron compound sodium decahydrodecaborate (GB-10) + EP in the hamster cheek pouch oral cancer model. " 08/01/2013 - "We previously proved the therapeutic success of BNCT mediated by the boron compounds boronophenylalanine and sodium decahydrodecaborate (GB-10) in the hamster cheek pouch oral cancer model. "
2.	Colonic Neoplasms (Colon Cancer) 07/11/2023 - "The aim of this study was to assess, in an ectopic colon cancer model, the therapeutic efficacy, radiotoxicity, abscopal effect and systemic immune response associated with (BPA/Borophenylalanine+GB-10/Decahydrodecaborate)-BNCT (Comb-BNCT) alone or in combination with Oligo-Fucoidan (O-Fuco) or Glutamine (GLN), compared to the "standard" BPA-BNCT protocol usually employed in clinical trials. "
3.	Arthritis (Polyarthritis) 11/01/2016 - "In a previous biodistribution study, we showed the incorporation of therapeutically useful boron concentrations to the pathological synovium in a model of antigen-induced arthritis (AIA) in rabbits, employing two boron compounds approved for their use in humans, i.e., decahydrodecaborate (GB-10) and boronophenylalanine (BPA). " 11/01/2014 - "The aim of the present study was to perform boron biodistribution studies in a model of antigen-induced arthritis (AIA) in female New Zealand rabbits, with the boron carriers boronophenylalanine (BPA) and sodium decahydrodecaborate (GB-10) to assess the potential feasibility of BNCS for RA. "
4.	Neoplasms (Cancer) 01/01/2019 - "We evaluated tumor control and toxicity in lung 2 weeks post-BNCT at 2 dose levels, including 5 experimental groups per dose level: T0 (euthanized pre-treatment), Boronophenylalanine-BNCT (BPA-BNCT), BPA + Sodium decahydrodecaborate-BNCT ((BPA + GB-10)-BNCT), Beam only (BO) and Sham (no treatment, same manipulation). "
5.	Neoplasm Metastasis (Metastasis) 06/01/2014 - "Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases."

Related Drugs and Biologics

1.	Glutamine (L-Glutamine)
2.	fucoidan
3.	Boron
4.	Sodium
5.	Antigens
6.	Boron Compounds
7.	salicylhydroxamic acid (SHAM)

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy