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LQB 118

has antineoplastic activity; structure in first source

Also Known As:

LQB-118; LQB118

Networked: 16 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Costa, Paulo R R: 9 articles (01/2019 - 12/2011)
2.	Costa, Paulo Roberto Ribeiro: 4 articles (06/2020 - 07/2011)
3.	Netto, Chaquip Daher: 4 articles (06/2020 - 07/2011)
4.	Rumjanek, Vivian M: 4 articles (01/2019 - 12/2011)
5.	Netto, Chaquip D: 4 articles (05/2017 - 12/2011)
6.	Maia, Raquel C: 3 articles (01/2019 - 12/2011)
7.	Salustiano, Eduardo J: 3 articles (01/2019 - 12/2011)
8.	Torres-Santos, Eduardo Caio: 3 articles (01/2018 - 07/2011)
9.	da Silva, Alcides J: 3 articles (02/2013 - 12/2011)
10.	Costas, Fernanda: 2 articles (12/2019 - 11/2014)

Related Diseases

1.	Cutaneous Leishmaniasis 01/01/2016 - "Our previous work demonstrated that LQB-118 was an effective treatment for experimental cutaneous leishmaniasis. " 01/01/2018 - "In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. " 07/01/2011 - "Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis."
2.	Visceral Leishmaniasis (Kala Azar) 01/01/2016 - "Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis." 05/01/2017 - "The racemic pterocarpanquinone LQB-118 is active, in mice and hamsters, against tegumentary and visceral leishmaniasis. "
3.	Leishmaniasis 01/01/2014 - "The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania (Viannia) braziliensis, which is the major Leishmania species related to American tegumentary leishmaniasis. " 01/01/2016 - "Our findings indicate that LQB-118 is effective at treating different clinical forms of leishmaniasis and presents no relevant signs of toxicity at therapeutic doses; thus, this framework is demonstrated suitable for developing promising drug candidates for the oral treatment of leishmaniasis."
4.	Inflammation (Inflammations) 06/01/2020 - "In this study, swiss mice were LQB 118 intraperitoneally (i.p.) treated and zymosan was used to induce peritoneal inflammation. " 06/01/2020 - "The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro."
5.	Body Weight (Weight, Body) 01/01/2016 - "In this study, we observed that treatment with 10 mg/kg of body weight/day LQB-118 orally inhibited the development of hepatosplenomegaly with a 99% reduction in parasite load. "

Related Drugs and Biologics

1.	Zymosan
2.	Transcription Factors (Transcription Factor)
3.	lapachol
4.	Inhibitor of Apoptosis Proteins
5.	Matrix Metalloproteinases (MMPs)
6.	Sirolimus (Rapamycin)
7.	Annexin A5
8.	Cyclins
9.	Messenger RNA (mRNA)
10.	Naphthoquinones