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CBS 9106

an exportin 1 inhibitor; structure in first source

Also Known As:

CBS-9106; CBS9106

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - CBS 9106: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - CBS 9106: 1
  - Pyridines: 88
    - Aminopyridines: 77
      - CBS 9106: 1

Experts

1.	Friedman, Jonathan M: 1 article (10/2011)
2.	Hasegawa, Yoko: 1 article (10/2011)
3.	Iwami, Tadahiko: 1 article (10/2011)
4.	Kawabe, Takumi: 1 article (10/2011)
5.	Kufe, Donald W: 1 article (10/2011)
6.	Saito, Naoya: 1 article (10/2011)
7.	Sakakibara, Keiichi: 1 article (10/2011)
8.	Sato, Takuji: 1 article (10/2011)
9.	Suzuki, Atsushi: 1 article (10/2011)
10.	Vonhoff, Daniel D: 1 article (10/2011)

Related Diseases

1.	Neoplasms (Cancer) 10/06/2011 - "In this study, we demonstrate that a novel compound, CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. " 10/06/2011 - "A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. " 10/06/2011 - "Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. "
2.	Multiple Myeloma 10/06/2011 - "In this study, we demonstrate that a novel compound, CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. "
3.	Body Weight (Weight, Body) 10/06/2011 - "Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. "

Related Drugs and Biologics

1.	Exportin 1 Protein

Related Therapies and Procedures

1.	Oral Administration