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Myopia 3

Also Known As:

MYP3

Networked: 27 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Eye Diseases: 3522
- Refractive Errors: 3499
  - Myopia: 8363
    - Myopia 3: 27

Related Diseases

1.	Myopia
2.	Carcinogenesis
3.	Uveitis
4.	Neoplasms (Cancer)
5.	Inflammation (Inflammations)

Experts

1.	Arnold, Lora L: 5 articles (07/2012 - 09/2002)
2.	Cohen, Samuel M: 5 articles (07/2012 - 09/2002)
3.	Hughes, Francis M: 3 articles (10/2021 - 12/2015)
4.	Pennington, Karen L: 3 articles (07/2012 - 06/2009)
5.	Le, X Chris: 3 articles (06/2009 - 09/2002)
6.	Dunton, Cody L: 2 articles (10/2021 - 09/2018)
7.	Nagatomi, Jiro: 2 articles (10/2021 - 09/2018)
8.	Purves, J Todd: 2 articles (10/2021 - 09/2018)
9.	Young, Terri L: 2 articles (09/2010 - 11/2004)
10.	Suzuki, Shugo: 2 articles (06/2009 - 07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myopia 3:

1.	Insulin-Like PeptidesIBA 01/01/2022 - "The insulin-like growth factor 1 (IGF1) gene is located within the myopia-associated MYP3 interval, which suggests it may play an important role in the progression of myopia. " 09/01/2010 - "Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. "
2.	Culture MediaIBA 10/01/2006 - "Yeast isolation was performed on conventional culture media (MYP), acidified (pH 3) media (MYP3), and on media prepared with water from the study sites (MYPw). "
3.	Gefitinib (Iressa)FDA Link 06/01/2009 - "In this study, we investigated the growth effects of As(III) and an organic trivalent arsenical, dimethylarsinous acid (DMA(III)), and the effects of co-exposure of gefitinib, an EGFR inhibitor, with As(III) to a rat urothelial cell line (MYP3). "
4.	dimethylarsinous acidIBA 06/01/2009 - "In this study, we investigated the growth effects of As(III) and an organic trivalent arsenical, dimethylarsinous acid (DMA(III)), and the effects of co-exposure of gefitinib, an EGFR inhibitor, with As(III) to a rat urothelial cell line (MYP3). "
5.	PH.3IBA 10/01/2006 - "Yeast isolation was performed on conventional culture media (MYP), acidified (pH 3) media (MYP3), and on media prepared with water from the study sites (MYPw). "
6.	AgarIBA 08/01/1999 - "MYP3 cells pretreated with or without MNU were exposed daily to LPS-activated PMN for one week and were then tested for growth in soft agar. " 10/15/1996 - "MYP3 cells pretreated with or without MNU were exposed to H202 (0.001 to 0.1 mM) daily for 1 week in monolayer culture and were then tested for growth in soft agar. " 08/01/1997 - "MYP3 cells pretreated with H2O2 were exposed to TNF-alpha (0 to 100 ng/ml) for 1 week in monolayer culture and were then subjected to growth in soft agar. " 08/01/1997 - "Using growth in soft agar and tumorigenicity in athymic nude mice as indices of transformation, we examined the effect of TNF-alpha on the enhancement of H2O2-initiated transformation of MYP3 cells; MYP3 is an anchorage-dependent nontumorigenic rat urothelial cell line. " 10/15/1995 - "Using soft agar growth as an index of transformation, we examined the effect of inflammation-associated cytokines on the enhancement of MNU-initiated transformation of MYP3 cells, an anchorage-dependent nontumorigenic rat bladder epithelial cell line. "
7.	CytokinesIBA 10/15/1995 - "Using soft agar growth as an index of transformation, we examined the effect of inflammation-associated cytokines on the enhancement of MNU-initiated transformation of MYP3 cells, an anchorage-dependent nontumorigenic rat bladder epithelial cell line. " 10/15/1996 - "Using growth in soft agar and tumorigenicity in athymic nude mice as indices of transformation, we examined the effect of H202 and cytokines on the enhancement of N-methyl-N-nitrosourea (MNU)-initiated transformation of MYP3 cells, an anchorage-dependent nontumorigenic rat bladder epithelial cell line. "
8.	Proteins (Proteins, Gene)FDA Link 04/01/2008 - "This new composite region is located between microsatellite marker D12S1684 at 75.8 K and SNP_A-1509586 (alias rs717996) at position 82,636,288 bp, and narrows the original 30.1 cM of the MYP3 interval to 6.8 cM. The refined MYP3 interval allowed us to restrict the list of database-indexed genes to 25, several of which are promising MYP3 candidates based on similarities with genes and proteins involved in vision physiology and eye disease. " 03/01/2006 - "Molecular analyses showed the deletion included the KERA gene, the SLRP (small leucine repeat protein) gene cluster, the genetic loci for autosomal-dominant (CNA1) and autosomal-recessive (CNA2) cornea plana, and a portion of the mapped locus for high myopia (MYP3). "
9.	Arsenicals (Arsenic Compounds)IBA 07/10/2008 - "Quantitation and speciation of arsenicals in the cell culture medium showed that MYP3 cells have some reductase activity but the cells do not methylate arsenicals. " 07/10/2008 - "To determine if MYP3 cells metabolize arsenicals, cells were treated with arsenate, arsenite and MMA(V) as described above and the medium was analyzed by HPLC-ICPMS to determine species and quantity of arsenicals present. " 09/01/2002 - "Using rat (MYP3) and human (1T1) urothelial cells, cytotoxicity for trivalent arsenicals, sodium arsenite, monomethylarsonous acid (MMA(III)), and DMA(III) was demonstrated at 0.4-4.8 microM concentrations, whereas MMA(V), DMA(V), and TMAO were cytotoxic at millimolar concentrations. "
10.	LumicanIBA 01/01/2016 - "Lumican (LUM) is a candidate gene for myopia in the MYP3 locus. " 11/30/2004 - "Lumican maps within the chromosome 12q21-q23 autosomal dominant high grade myopia-3 (MYP3) interval, and fibromodulin maps to chromosome 1q32. " 11/30/2004 - "Sequencing of the human lumican and fibromodulin genes has excluded them as candidate genes for MYP3 associated high grade myopia." 11/30/2004 - "We screened individuals for lumican and fibromodulin sequence alterations from the original MYP3 family, and from a second high grade myopia pedigree that showed suggestive linkage to both the MYP3 interval and to chromosome 1q32. " 11/30/2004 - "Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia."

Therapies and Procedures

1.	Glycemic Control 09/01/2010 - "Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. "
2.	Laser In Situ Keratomileusis (LASIK) 05/15/2021 - "Matched comparison of corneal higher order aberrations induced by SMILE to femtosecond assisted LASIK and to PRK in correcting moderate and high myopia: 3.00mm vs. 6.00mm." 11/01/2015 - "The patient had undergone LASIK procedure for high myopia 3 months previously. "
3.	Vitreoretinal Surgery 01/01/2019 - "The predisposing factors for late in-the-bag spontaneous IOL dislocations were pseudoexfoliation [PEX; 12/39 (30.8%)], previous vitreoretinal surgery [7/39 (17.9%)], axial myopia [3/39 (7.7%)], both PEX and axial myopia [1/39 (2.6%)], both previous vitreoretinal surgery and axial myopia [2/39 (5.1%)] and uveitis [1/39 (2.6%)]. "
4.	Epikeratophakia 02/01/1988 - "Six epikeratoplasty (EKP) specimens were obtained 1 to 10 months after refractive keratoplasty for aphakia (2 cases), keratoconus (1 case), and myopia (3 cases). "
5.	Corneal Transplantation (Keratoplasty) 02/01/1988 - "Six epikeratoplasty (EKP) specimens were obtained 1 to 10 months after refractive keratoplasty for aphakia (2 cases), keratoconus (1 case), and myopia (3 cases). "