Wolfram Syndrome 2

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Otorhinolaryngologic Diseases: 203
- Ear Diseases: 261
  - Hearing Disorders: 325
    - Hearing Loss: 12265
      - Sensorineural Hearing Loss: 3974
        Wolfram Syndrome 2: 10
Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Sensation Disorders: 117
    - Hearing Disorders: 325
      - Hearing Loss: 12265
        Sensorineural Hearing Loss: 3974
        Wolfram Syndrome 2: 10
- Cranial Nerve Diseases: 554
  - Optic Nerve Diseases: 2663
    - Optic Atrophy: 819
      - Wolfram Syndrome 2: 10
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Sensation Disorders: 117
      - Hearing Disorders: 325
        Hearing Loss: 12265
        Sensorineural Hearing Loss: 3974
        Wolfram Syndrome 2: 10
  - Premature Aging: 1168
    - Wolfram Syndrome 2: 10
Eye Diseases: 3522
- Optic Nerve Diseases: 2663
  - Optic Atrophy: 819
    - Wolfram Syndrome 2: 10
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Mitochondrial Diseases: 21919
    - Wolfram Syndrome 2: 10

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary)
2.	Mitochondrial Diseases (Mitochondrial Disease)
3.	Neurodegenerative Diseases (Neurodegenerative Disease)
4.	Neoplasms (Cancer)
5.	Type 2 Diabetes Mellitus (MODY)

Experts

1.	Jennings, Patricia A: 3 articles (06/2015 - 09/2009)
2.	Nechushtai, Rachel: 3 articles (06/2015 - 09/2009)
3.	Paddock, Mark L: 3 articles (06/2015 - 09/2009)
4.	Huang, Yi-Long: 2 articles (01/2021 - 01/2018)
5.	Kao, Cheng-Heng: 2 articles (01/2021 - 01/2018)
6.	Shen, Zhao-Qing: 2 articles (01/2021 - 01/2018)
7.	Teng, Yuan-Chi: 2 articles (01/2021 - 01/2018)
8.	Tsai, Ting-Fen: 2 articles (01/2021 - 01/2018)
9.	Agranat, Lily: 2 articles (06/2015 - 01/2013)
10.	Lipper, Colin H: 2 articles (06/2015 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wolfram Syndrome 2:

1.	Proteins (Proteins, Gene)FDA Link 09/11/2009 - "Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2." 10/01/2007 - "A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2." 06/01/2015 - "Abnormal regulation of NEET proteins was consequently found to result in multiple health conditions, and aberrant splicing of NAF-1 was found to be a causative of the neurological genetic disorder Wolfram Syndrome 2. Here we review the discovery of NEET proteins, their structural, biochemical and biophysical characterization, and their most recent structure-function analyses. " 01/01/2023 - "Recently, these proteins have revealed themselves as attractive drug targets for mitochondrial dysfunction-related diseases, such as type 2 diabetes, Wolfram syndrome 2, and cancers. " 02/03/2010 - "Here, we identify the BCL-2-interacting protein at the ER, nutrient-deprivation autophagy factor-1 (NAF-1)-a bitopic integral membrane protein whose defective expression underlies the aetiology of the neurodegenerative disorder Wolfram syndrome 2 (WFS2). "
2.	SulfurIBA 01/01/2023 - "CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for Wolfram syndrome 2 (WFS2; MIM 604928). " 11/13/2022 - "CDGSH iron-sulfur domain 2 (CISD2), the causative gene for Wolfram syndrome 2 (WFS2; MIM 604928), plays a pivotal role in mediating lifespan and healthspan by maintaining mitochondrial function, endoplasmic reticulum integrity, intracellular Ca2+ homeostasis, and redox status. " 01/01/2021 - "CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder showing metabolic and neurodegenerative manifestations. "
3.	IronIBA 01/01/2023 - "CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for Wolfram syndrome 2 (WFS2; MIM 604928). " 11/13/2022 - "CDGSH iron-sulfur domain 2 (CISD2), the causative gene for Wolfram syndrome 2 (WFS2; MIM 604928), plays a pivotal role in mediating lifespan and healthspan by maintaining mitochondrial function, endoplasmic reticulum integrity, intracellular Ca2+ homeostasis, and redox status. " 01/01/2021 - "CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder showing metabolic and neurodegenerative manifestations. "
4.	Staphylococcal Protein A (Protein A)IBA 01/01/2018 - "Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice. "
5.	Membrane Proteins (Integral Membrane Proteins)IBA 02/03/2010 - "Here, we identify the BCL-2-interacting protein at the ER, nutrient-deprivation autophagy factor-1 (NAF-1)-a bitopic integral membrane protein whose defective expression underlies the aetiology of the neurodegenerative disorder Wolfram syndrome 2 (WFS2). "
6.	CalciumIBA 01/01/2013 - "It was implicated in human pathology (Wolfram Syndrome 2) and in BCL-2 mediated antagonization of Beclin 1-dependent autophagy and depression of ER calcium stores. "