4 Insulin-Dependent Diabetes Mellitus

Also Known As:

Diabetes Mellitus, Insulin-Dependent, 4; IDDM4; Insulin-Dependent Diabetes Mellitus 4

Networked: 12 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Glucose Metabolism Disorders: 375
    - Diabetes Mellitus: 56563
      - Type 1 Diabetes Mellitus: 36799
        4 Insulin-Dependent Diabetes Mellitus: 12
Endocrine System Diseases: 968
- Diabetes Mellitus: 56563
  - Type 1 Diabetes Mellitus: 36799
    - 4 Insulin-Dependent Diabetes Mellitus: 12
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Type 1 Diabetes Mellitus: 36799
    - 4 Insulin-Dependent Diabetes Mellitus: 12

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2.	Ketosis
3.	Diabetes Mellitus
4.	Body Weight (Weight, Body)
5.	3 Insulin-Dependent Diabetes Mellitus

Experts

1.	Blankenhorn, Elizabeth P: 3 articles (04/2007 - 11/2002)
2.	Greiner, Dale L: 3 articles (04/2007 - 11/2002)
3.	Mordes, John P: 3 articles (04/2007 - 11/2002)
4.	Rodemich, Lucy: 2 articles (04/2007 - 04/2005)
5.	Leif, Jean: 2 articles (04/2005 - 11/2002)
6.	Hornum, Lars: 1 article (09/2007)
7.	Lundsgaard, Dorthe: 1 article (09/2007)
8.	Markholst, Helle: 1 article (09/2007)
9.	Cort, Laura: 1 article (04/2007)
10.	Descipio, Cheryl: 1 article (04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 4 Insulin-Dependent Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 12/15/1996 - "Now that it has been colocalized in 11q13.3 with IDDM4, a diabetes susceptibility locus, alterations in FADD should also be considered as potential contributors to insulin-dependent familial diabetes. " 01/01/2000 - "Previous studies have identified a susceptibility region for insulin-dependent (type 1) diabetes mellitus on chromosome 11q13 (IDDM4). " 06/01/1989 - "Diabetes mellitus was characterised as follows: (1) it was strictly insulin-dependent and ketosis-prone, (2) the average insulin requirement was 1 U/kg body weight, (3) the HLA haplotype was not typical of Type 1 (insulin-dependent) diabetes mellitus, (4) there were no positive immune parameters typical of Type 1 diabetes at the clinical onset of diabetes mellitus and (5) there was no remission. "
2.	Poly I-CIBA 04/01/2007 - "Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. " 04/01/2005 - "Surprisingly, an analysis of 190 (BBDR x WF)F2 rats treated with KRV after brief exposure to poly I:C revealed that the BBDR-origin allele of Iddm4 is necessary but not entirely sufficient for diabetes expression. " 04/01/2005 - "The dominant diabetes susceptibility locus Iddm4 is required for diabetes induced by treatment with poly I:C plus Treg depletion. " 11/01/2002 - "We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2(+) regulatory cells. "
3.	HLA-DR beta-ChainsIBA 01/01/1986 - "Three HLA-DR beta genes were isolated from a Swedish HLA-DR3/4 insulin-dependent diabetes mellitus (IDDM) patient and characterized by restriction endonuclease mapping and nucleotide sequence analysis. "
4.	Toll-Like Receptor 3IBA 09/01/2007 - "The Iddm4 gene controls diabetes in rats depleted of regulatory T cells (T reg) and immune-activated via treatment with the toll-like receptor 3 (TLR-3) ligand, polyI:C. "
5.	Trinitrotoluene (TNT)IBA 04/17/1998 - "The genetic analysis of Iddm1 and Iddm2 homozygous [(BB/OK x SHR)F1 x BB/OK] first backcross hybrids (BC1) confirmed the action of Iddm3 and one predisposing non-MHC locus, Iddm4, near Ighe/D6Mgh2 on chromosome 6 and one protective locus, Iddm5r(esistance), detected around Igf2/Tnt on chromosome 1. From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes."
6.	Proteins (Proteins, Gene)FDA Link 08/17/1998 - "A gene encoding a novel transmembrane protein was identified by DNA sequence analysis within the insulin-dependent diabetes mellitus (IDDM) locus IDDM4 on chromosome 11q13. "
7.	LigandsIBA 09/01/2007 - "The Iddm4 gene controls diabetes in rats depleted of regulatory T cells (T reg) and immune-activated via treatment with the toll-like receptor 3 (TLR-3) ligand, polyI:C. "
8.	DNA Restriction Enzymes (Restriction Endonuclease)IBA 01/01/1986 - "Three HLA-DR beta genes were isolated from a Swedish HLA-DR3/4 insulin-dependent diabetes mellitus (IDDM) patient and characterized by restriction endonuclease mapping and nucleotide sequence analysis. "
9.	Blood Glucose (Blood Sugar)IBA 11/01/1998 - "Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat."
10.	polyacrylamideIBA 06/01/2001 - "The polymorphisms of short tandem repeat (STR) loci D15S657, D11S1369, D6S2420 and D6S503, linked to IDDM3, IDDM4, IDDM5 and IDDM8 respectively, were studied by polymerase chain reaction and polyacrylamide gel electrophoresis (PCR-PAGE) followed by direct sequencing of PCR products in 105 normal Chinese Han nationality subjects and 48 patients with IDDM. "

Therapies and Procedures

Aftercare (After-Treatment)

11/01/2002 - "We have now developed lines of congenic WF.iddm4 rats and report that in an intercross of N5 generation WF.iddm4 rats, approximately 70% of animals either homozygous or heterozygous for the BBDR origin allele of iddm4 became hyperglycemic after treatment to induce diabetes. "
11/01/2002 - "We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2(+) regulatory cells. "