5 Insulin-Dependent Diabetes Mellitus

Also Known As:

Diabetes Mellitus, Insulin-Dependent, 5; IDDM5; Insulin-Dependent Diabetes Mellitus 5

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Glucose Metabolism Disorders: 375
    - Diabetes Mellitus: 56563
      - Type 1 Diabetes Mellitus: 36799
        5 Insulin-Dependent Diabetes Mellitus: 12
Endocrine System Diseases: 968
- Diabetes Mellitus: 56563
  - Type 1 Diabetes Mellitus: 36799
    - 5 Insulin-Dependent Diabetes Mellitus: 12
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Type 1 Diabetes Mellitus: 36799
    - 5 Insulin-Dependent Diabetes Mellitus: 12

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2.	Renal Insufficiency (Renal Failure)
3.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
4.	Neoplasms (Cancer)
5.	Inflammation (Inflammations)

Experts

1.	Wang, Cong-Yi: 4 articles (01/2017 - 08/2004)
2.	She, Jin-Xiong: 3 articles (02/2008 - 08/2004)
3.	Yang, Ping: 2 articles (01/2017 - 08/2004)
4.	Park, Yongsoo: 2 articles (10/2006 - 08/2004)
5.	Chen, Zhishui: 1 article (01/2017)
6.	Zhang, Jing: 1 article (01/2017)
7.	Zhou, Zhiguang: 1 article (01/2017)
8.	Bergholdt, Regine: 1 article (01/2008)
9.	Brorsson, Caroline: 1 article (01/2008)
10.	Christgau, Stephan: 1 article (01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 5 Insulin-Dependent Diabetes Mellitus:

1.	UbiquitinIBA 01/01/2017 - "In 2004, we first reported the cloning of a novel small ubiquitin -like modifier (SUMO) gene, SUMO4, in the IDDM5 region on chromosome 6q25, and presented strong genetic and functional evidence suggesting that SUMO4 could be a novel T1D susceptibility gene. " 02/01/2008 - "In 2004, we first reported the cloning of a novel, small ubiquitin-like modifier (SUMO) gene, SUMO4, in the IDDM5 interval on chromosome 6q25, and presented strong genetic and functional evidence suggesting that SUMO4 is a T1D susceptibility gene. " 06/01/2007 - "Small ubiquitin-like modifier 4 (SUMO4) has been identified as a candidate gene for the IDDM5 locus and suggested to have possible involvement in immune responses, such as autoimmunity and inflammation. " 06/01/2007 - "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population." 10/01/2006 - "Small ubiquitin-related modifier (SUMO4), located in IDDM5, has been identified as a potential susceptibility gene for type 1 diabetes mellitus (T1DM). "
2.	Protein D-Aspartate-L-Isoaspartate Methyltransferase (Protein L Isoaspartate D Aspartate O Methyltransferase)IBA 01/01/2008 - "Protein L-isoaspartate (D-aspartate) O-methyltransferase (PIMT) repairs modified proteins and is encoded by PCMT1, located in a region linked to type 1 diabetes (T1D), namely IDDM5. "
3.	Valine (L-Valine)FDA Link 11/01/2005 - "An association of a methionine-to-valine polymorphism (rs237025, 163A --> G, M55V) in the SUMO4 gene within IDDM5 has recently been described in T1D. "
4.	Rheumatoid FactorIBA 11/01/2005 - "Linkage and association of rheumatoid arthritis (RA) and rheumatoid factor (RF)-negative juvenile idiopathic arthritis (JIA) has previously been demonstrated to the type 1 diabetes (T1D) locus, IDDM5, on chromosome 6q25. "
5.	Proteins (Proteins, Gene)FDA Link 01/01/2008 - "Protein L-isoaspartate (D-aspartate) O-methyltransferase (PIMT) repairs modified proteins and is encoded by PCMT1, located in a region linked to type 1 diabetes (T1D), namely IDDM5. "
6.	Methionine (L-Methionine)FDA Link 11/01/2005 - "An association of a methionine-to-valine polymorphism (rs237025, 163A --> G, M55V) in the SUMO4 gene within IDDM5 has recently been described in T1D. "
7.	Insulin (Novolin)FDA Link 11/01/1988 - "The effect of low-dose insulin treatment (5-10 U/h) on hepatic glucose production (HGP) and peripheral glucose disposal was determined in 5 insulin-dependent diabetes mellitus (IDDM) subjects who were admitted with diabetic ketoacidosis (DKA; plasma glucose 598 +/- 50 mg/dl, blood pH 7.20 +/- 0.06, plasma bicarbonate 12 +/- 2 meq/L). "
8.	Immunoglobulin Allotypes (Immunoglobulin Allotype)IBA 01/01/1989 - "The following Gm and Km immunoglobulin allotypes were determined on the Genetic Analysis Workshop 5 insulin-dependent diabetes mellitus (GAW5 IDDM) families: G1m (1,2,3,17), G2m (23), G3m (5,10,11,13,14,21,28) and Km (1,3). "
9.	Glucose (Dextrose)FDA LinkGeneric 11/01/1988 - "The effect of low-dose insulin treatment (5-10 U/h) on hepatic glucose production (HGP) and peripheral glucose disposal was determined in 5 insulin-dependent diabetes mellitus (IDDM) subjects who were admitted with diabetic ketoacidosis (DKA; plasma glucose 598 +/- 50 mg/dl, blood pH 7.20 +/- 0.06, plasma bicarbonate 12 +/- 2 meq/L). "
10.	DNA (Deoxyribonucleic Acid)IBA 08/01/2004 - "Here, we report evidence for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval. "

Therapies and Procedures

1.	Kidney Transplantation 10/01/1994 - "From November 1985 to July 1993, 29 out of 241 patients (12%) who underwent heart transplantation (HTx) at our institution had one or more "classical" contraindications to HTx: age > or = 60 years (20 patients); insulin-dependent diabetes mellitus (5 patients); irreversible renal failure requiring combined heart-kidney transplantation (2 patients); previous surgery for malignancy (1 patient); familial hypercholesterolemia (1 patient) and active systemic infection (1 patient). "
2.	Heart Transplantation (Grafting, Heart) 10/01/1994 - "From November 1985 to July 1993, 29 out of 241 patients (12%) who underwent heart transplantation (HTx) at our institution had one or more "classical" contraindications to HTx: age > or = 60 years (20 patients); insulin-dependent diabetes mellitus (5 patients); irreversible renal failure requiring combined heart-kidney transplantation (2 patients); previous surgery for malignancy (1 patient); familial hypercholesterolemia (1 patient) and active systemic infection (1 patient). "
3.	Contraindications 10/01/1994 - "From November 1985 to July 1993, 29 out of 241 patients (12%) who underwent heart transplantation (HTx) at our institution had one or more "classical" contraindications to HTx: age > or = 60 years (20 patients); insulin-dependent diabetes mellitus (5 patients); irreversible renal failure requiring combined heart-kidney transplantation (2 patients); previous surgery for malignancy (1 patient); familial hypercholesterolemia (1 patient) and active systemic infection (1 patient). "