12 Insulin-Dependent Diabetes Mellitus

Also Known As:

Diabetes Mellitus, Insulin-Dependent, 12; IDDM12; Insulin-Dependent Diabetes Mellitus 12

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Glucose Metabolism Disorders: 375
    - Diabetes Mellitus: 56563
      - Type 1 Diabetes Mellitus: 36799
        12 Insulin-Dependent Diabetes Mellitus: 13
Endocrine System Diseases: 968
- Diabetes Mellitus: 56563
  - Type 1 Diabetes Mellitus: 36799
    - 12 Insulin-Dependent Diabetes Mellitus: 13
Immune System Diseases: 4321
- Autoimmune Diseases: 34618
  - Type 1 Diabetes Mellitus: 36799
    - 12 Insulin-Dependent Diabetes Mellitus: 13

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2.	13 Insulin-Dependent Diabetes Mellitus
3.	Thyroid Diseases (Thyroid Disease)
4.	7 Insulin-Dependent Diabetes Mellitus
5.	Genetic Predisposition to Disease (Genetic Predisposition)

Experts

1.	Sugihara, Shigetaka: 1 article (10/2012)
2.	Park, Yongsoo: 1 article (09/2007)
3.	Bartsocas, Christos S: 1 article (08/2006)
4.	Gerasimidi-Vazeou, Andriani: 1 article (08/2006)
5.	Dupont, Bo: 1 article (12/2005)
6.	Felner, Eric I: 1 article (12/2005)
7.	Ham, Melissa: 1 article (12/2005)
8.	Klitz, William: 1 article (12/2005)
9.	Lazaro, Ana M: 1 article (12/2005)
10.	Stastny, Peter: 1 article (12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 12 Insulin-Dependent Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 01/01/2001 - "Polymorphisms in the regulatory region of the insulin gene (designated IDDM2), polymorphisms in cytotoxic T lymphocyte antigen-4 (CTLA-4) gene (IDDM12), and other genes are likely to contribute to diabetes risk and susceptibility in some individuals. " 01/01/1999 - "IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent)." 01/01/1998 - "Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population." 09/01/2001 - "We examined the variable number of tandem repeats in the promoter region of the insulin gene (INS-VNTR, insulin-dependent diabetes mellitus (IDDM) 2) and cytotoxic T lymphocyte antigen 4 (CTLA4, IDDM12) as representative of Type 1 diabetes susceptibility genes. " 10/01/2012 - "Several genes, including those encoding human leukocyte antigen (HLA) class II (IDDM1 locus), insulin (IDDM2 locus), and cytotoxic T lymphocyte antigen (CTLA) 4 (IDDM12 locus), are involved in this process. "
2.	CTLA-4 AntigenIBA 09/01/2007 - "The polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4, IDDM12) encoding a regulatory molecule in the immune system associate with T1D and autoimmune thyroid diseases (ATD). " 09/01/2001 - "We examined the variable number of tandem repeats in the promoter region of the insulin gene (INS-VNTR, insulin-dependent diabetes mellitus (IDDM) 2) and cytotoxic T lymphocyte antigen 4 (CTLA4, IDDM12) as representative of Type 1 diabetes susceptibility genes. "
3.	HLA Antigens (Human Leukocyte Antigens)IBA 10/01/2012 - "Several genes, including those encoding human leukocyte antigen (HLA) class II (IDDM1 locus), insulin (IDDM2 locus), and cytotoxic T lymphocyte antigen (CTLA) 4 (IDDM12 locus), are involved in this process. " 12/01/2005 - "The genetic component of T1DM is in large part related to genes from the human leukocyte antigen (HLA) complex (IDDM1); however, loci from the variable nucleotide tandem repeat (VNTR) region of the insulin (INS) gene (IDDM2) and more recently, the cytotoxic T-lymphocyte-associated protein-4 region (CTLA4, IDDM12) have also been implicated. "
4.	AntigensIBA 08/01/2006 - "However, it has been shown recently that cytotoxic lymphocyte antigen 4 (CTLA4) on chromosome 2q33 (IDDM12) and LYP/PTPN22 on chromosome 1p13 also contribute to the genetic risk of T1DM. " 10/01/2012 - "Several genes, including those encoding human leukocyte antigen (HLA) class II (IDDM1 locus), insulin (IDDM2 locus), and cytotoxic T lymphocyte antigen (CTLA) 4 (IDDM12 locus), are involved in this process. "
5.	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/01/2004 - "TGF-beta1 was also measured in 38 patients with type 1 (insulin-dependent) diabetes mellitus (12 with newly diagnosed diabetes, 26 long-standing diabetes) and 31 healthy controls. "
6.	Natriuretic AgentsIBA 11/01/1986 - "In order to determine whether atrial natriuretic hormone (ANH) secretion is altered in diabetic patients with autonomic neuropathy, plasma immunoreactive ANH (IR-ANH) levels were measured in 23 patients with insulin-dependent diabetes mellitus, 12 of whom had definite cardiac autonomic neuropathy determined by noninvasive maneuvers. "
7.	NucleotidesIBA 12/01/2005 - "The genetic component of T1DM is in large part related to genes from the human leukocyte antigen (HLA) complex (IDDM1); however, loci from the variable nucleotide tandem repeat (VNTR) region of the insulin (INS) gene (IDDM2) and more recently, the cytotoxic T-lymphocyte-associated protein-4 region (CTLA4, IDDM12) have also been implicated. "
8.	Interleukin-1 (Interleukin 1)IBA 11/01/1998 - "Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. "
9.	HLA-DQB1 antigen (HLA DQB1)IBA 03/01/2004 - "IDDM12 showed MLS=2.0 in HLA-DQB1 identical sib pairs. "
10.	P-2 (P 2)IBA 10/01/2001 - "Three chromosome regions were identified that showed significant evidence of linkage (P<2.2x10(-5); LOD scores >4), 6p21 (IDDM1), 11p15 (IDDM2), 16q22-q24, and four more that showed suggestive evidence (P<7.4x10(-4), LOD scores > or =2.2), 10p11 (IDDM10), 2q31 (IDDM7, IDDM12, and IDDM13), 6q21 (IDDM15), and 1q42. "