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2- (4- acetyloxycyclohexylamino)- 4- (3,6,6- trimethyl- 4- oxo- 4,5,6,7- tetrahydro- 1H- indazol- 1- yl)- benzamide

has antiviral activity against HSV-1; structure in first source

Also Known As:

BJ-B11

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        2-(4-acetyloxycyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-benzamide: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - 2-(4-acetyloxycyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-benzamide: 4

Experts

1.	Wang, Yi-Fei: 3 articles (12/2012 - 03/2011)
2.	Xia, Min: 3 articles (12/2012 - 03/2011)
3.	Xiang, Yang-Fei: 3 articles (12/2012 - 03/2011)
4.	Chen, Zhen-Ping: 2 articles (12/2012 - 09/2011)
5.	Liu, Zhong: 2 articles (12/2012 - 09/2011)
6.	Wang, Shao-Xiang: 2 articles (12/2012 - 09/2011)
7.	Ju, Huai-Qiang: 2 articles (09/2011 - 03/2011)
8.	Wang, Sha-Yan: 2 articles (09/2011 - 03/2011)
9.	Xing, Guo-Wen: 2 articles (09/2011 - 03/2011)
10.	Chen, Juan: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Moreover, BJ-B11 inhibited tumor growth in xenograft model. " 12/01/2012 - "BJ-B11 is a selective heat shock protein 90 (Hsp90) inhibitor that has been reported to possess significant antitumor activity in multiple types of cancer cells; however, the mechanism of action needs to be further clarified. "
2.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/01/2011 - "BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway." 09/01/2011 - "Taken together, our data provide a putative molecular mechanism for the anticancer effect of BJ-B11 on K562 cells, and suggest a potential application for BJ-B11 in chronic myeloid leukemia therapy."
3.	Infections 03/15/2011 - "Additionally, the inhibitory effects of BJ-B11 against HSV-1 were likely to be introduced at early stage of infection. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/01/2012 - "The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells."
5.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "Altogether, Hsp90 activation is a risk factor in breast cancer patients, and BJ-B11 could be used to treat breast cancer." 01/01/2019 - "BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells."

Related Drugs and Biologics

1.	Heat-Shock Proteins (Heat-Shock Protein)

Related Therapies and Procedures

1.	Therapeutics