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ganodermanontriol

an antineoplastic agent; isolated from Ganoderma lucidum; structure in first source

Also Known As:

GNDT triterpene

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jiang, Jiahua: 3 articles (11/2011 - 03/2011)
2.	Sliva, Daniel: 3 articles (11/2011 - 03/2011)
3.	Jedinak, Andrej: 2 articles (11/2011 - 03/2011)
4.	Bharadwaj, Shiv: 1 article (12/2019)
5.	Dwivedi, Vivek Dhar: 1 article (12/2019)
6.	Kang, Sang Gu: 1 article (12/2019)
7.	Lee, Kyung Eun: 1 article (12/2019)
8.	Lucas, Stuart J: 1 article (12/2019)
9.	Pandey, Amit: 1 article (12/2019)
10.	Panwar, Aleksha: 1 article (12/2019)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2018 - "The cancer cells were treated with ganodermanontriol. " 03/01/2011 - "In conclusion, our data suggest that ganodermanontriol might be a potential chemotherapeutic agent for the treatment of cancer." 12/01/2018 - "This study explored mainly on the mechanism how ganodermanontriol affects the expression of SATB1 and inhibits proliferation of tumor on human hepatoma cell line HepG2. " 12/01/2018 - "In HepG2 cancer cells treated with various concentrations of ganodermanontriol, the cell proliferation of was detected by MTT assay, cell apoptosis was analyzed by flow cytometry; the mRNA of SATB1, Bcl-2, Bax were detected by reverse transcription-polymerase chain reaction (RT-PCR) and the protein level of SATB1, Bcl-2, Bax, and caspase 3 were analyzed by Western blot. "
2.	Inflammation (Inflammations) 12/12/2013 - "This study targets the evaluation of hepatoprotective activity of ganodermanontriol, a sterol isolated from Ganoderma lucidum, and the investigation of its mechanism of action in Hepa1c1c7 and murine liver cells upon tert-butyl hydroperoxide (t-BHP)-induced inflammation. " 01/01/2023 - "Furthermore, we determined the major components of GLSP triterpenes, including Ganoderic acid A, Ganoderic acid B, Ganoderic acid C6, Ganoderic acid G, and Ganodermanontriol, and found that these triterpenes promoted ABCA1/G1-mediated cholesterol efflux and inhibited inflammation in macrophage, and inactivated RUNX2-mediated osteogenesis in VSMC. "
3.	Neoplasm Metastasis (Metastasis) 12/01/2018 - "This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2018 - "This study explored mainly on the mechanism how ganodermanontriol affects the expression of SATB1 and inhibits proliferation of tumor on human hepatoma cell line HepG2. " 12/01/2018 - "This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). " 12/01/2018 - "Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma."
5.	Breast Neoplasms (Breast Cancer) 11/28/2011 - "The effect of ganodermanontriol and its isomers on cell proliferation was assayed; IC50 values of 5.8 and 9.7 μM on breast cancer cell lines MCF-7 and MDA-MB-231, respectively, were found for ganodermanontriol." 11/28/2011 - "Ganodermanontriol showed promising activity on the inhibition and proliferation of breast cancer cells. " 11/18/2011 - "Here we show that ganodermanontriol (GDNT), a Ganoderma alcohol, specifically suppressed proliferation (anchorage-dependent growth) and colony formation (anchorage-independent growth) of highly invasive human breast cancer cells MDA-MB-231. " 11/18/2011 - "Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA."

Related Drugs and Biologics

1.	tert-Butylhydroperoxide
2.	Sterols
3.	Triterpenes
4.	Caspase 3 (Caspase-3)
5.	Catenins
6.	Messenger RNA (mRNA)
7.	Proteins (Proteins, Gene)
8.	Cholesterol
9.	Carrier Proteins (Binding Protein)
10.	ganoderic acid