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1- biphenyl- 4- yl- 2- (4- nitrophenoxy)ethanone

inhibits Protein Tyrosine Phosphatase 1B; an antihyperglycemic agent; structure in first source

Also Known As:

VMNS2e

Networked: 2 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        1-biphenyl-4-yl-2-(4-nitrophenoxy)ethanone: 2

Experts

1.	Bodhankar, Subhash L: 2 articles (01/2011 - 12/2010)
2.	Ghole, Vikram S: 2 articles (01/2011 - 12/2010)
3.	Kodam, Kisan M: 2 articles (01/2011 - 12/2010)
4.	Kulkarni, Vithal M: 2 articles (01/2011 - 12/2010)
5.	Kurundkar, Sucheta B: 2 articles (01/2011 - 12/2010)
6.	Sachan, Narsingh: 2 articles (01/2011 - 12/2010)
7.	D'Souza, Serena: 1 article (12/2010)
8.	Vanage, Geeta: 1 article (12/2010)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 12/01/2010 - "It is concluded that VMNS2e treatment at 30 and 60 mg/kg, when given for 8 weeks, partly ameliorated early diabetic nephropathy in diabetic rats." 12/01/2010 - "Novel biphenyl compound, VMNS2e, ameliorates streptozotocin-induced diabetic nephropathy in rats." 12/01/2010 - "To study the effect of a new biphenyl synthetic compound showing interactions with the active site of protein tyrosine phosphatase 1B by docking and molecular dynamics, VMNS2e in streptozotocin-induced diabetic nephropathy in rats with various renal function parameters and renal ultrastructure. "
2.	Insulin Resistance 01/10/2011 - "VMNS2e exhibited both acute and chronic anti hyperglycemic effect, insulin sensitivity along with improvement in various lipid parameters and glycemic control."
3.	Body Weight (Weight, Body) 01/10/2011 - "VMNS2e treatment had no significant effect on body weight and food consumption. "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	diphenyl (biphenyl)
3.	Lipids
4.	Non-Receptor Type 1 Protein Tyrosine Phosphatase

Related Therapies and Procedures

1.	Glycemic Control