lagunamide A

cytotoxic and antimalarial cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula; structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

1.	Neoplasms (Cancer) 11/07/2016 - "In this study, we have systematically investigated the structure-activity relationships (SARs) of a concise collection of lagunamide A and its analogues constructed by total chemical synthesis against a broad panel of cancer cells derived from various tissues or organs, including A549, HeLa, U2OS, HepG2, BEL-7404, BGC-823, HCT116, MCF-7, HL-60, and A375. " 05/01/2012 - "Lagunamide A exhibited a selective growth inhibitory activity against a panel of cancer cell lines, including P388, A549, PC3, HCT8, and SK-OV3 cells, with IC₅₀ values ranging from 1.6 nM to 6.4 nM. Morphological studies showed blebbing at the surface of cancer cells as well as cell shrinkage accompanied by loss of contact with the substratum and neighboring cells. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 11/07/2016 - "Accompanied with the dissipation of mitochondrial membrane potential (Δφm) and overproduction of reactive oxygen species (ROS), lagunamide A led to mitochondrial dysfunction and finally caused cell death. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 11/07/2016 - "Moreover, both anti- and pro-apoptotic B-cell lymphoma 2 (Bcl-2) family proteins participated in lagunamide A-induced mitochondrial apoptosis, especially myeloid cell leukemia-1 (Mcl-1). "

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Proteins (Proteins, Gene)