PKF115-584

an inhibitor of WNT signaling, effectively induce apoptosis in acute myeloid leukemia cells; structure in first source

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        Perylene: 61
        PKF115-584: 5
        Phenalenes: 1
        Perylene: 61
        PKF115-584: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Perylene: 61
      - PKF115-584: 5
  - Phenalenes: 1
    - Perylene: 61
      - PKF115-584: 5

Experts

1.	Busch, Christian: 1 article (01/2018)
2.	Cheng, Phil F: 1 article (01/2018)
3.	Garbe, Claus: 1 article (01/2018)
4.	Ikenberg, Kristian: 1 article (01/2018)
5.	Krochmann, Jelena: 1 article (01/2018)
6.	Levesque, Mitchell P: 1 article (01/2018)
7.	Meraz-Torres, Francisco: 1 article (01/2018)
8.	Niessner, Heike: 1 article (01/2018)
9.	Sinnberg, Tobias: 1 article (01/2018)
10.	Brussolo, Stefania: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2007 - "In xenograft models of human MM, PKF115-584 inhibits tumor growth and prolongs survival. " 04/01/2010 - "In vivo studies exhibited tumor inhibition of 69% with CGP049090 and 57% with PKF115-584 when compared with vehicle-treated controls, and the intervention was well tolerated. " 04/01/2010 - "CGP049090 or PKF115-584 may be attractive compounds for CLL and other malignancies that deserve further (pre)clinical evaluation." 08/01/2008 - "The objective of the study was to investigate the effect of the small-molecule inhibitor of the T cell factor (Tcf)/beta-catenin complex PKF115-584 on beta-catenin-dependent transcription and proliferation of H295R adrenocortical tumor cells, which harbor mutations in CTNNB1 as well as the TP53 tumor suppressor gene. "
2.	Adrenocortical Carcinoma 08/01/2008 - "The T cell factor/beta-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells."
3.	Neoplasm Metastasis (Metastasis) 01/01/2018 - "Similarly, knockdown of β-catenin impaired intradermal melanoma cell invasion and PKF115-584 efficiently reduced liver metastasis in a chick chorioallantoic membrane model. "
4.	Melanoma (Melanoma, Malignant) 01/01/2018 - "Fibroblast derived Wnt3a reduced melanoma cell adhesion and enhanced migration, while the β-catenin inhibitor PKF115-584 increased adhesion and reduced migration in vitro and in the chick embryonic neural crest environment in vivo. " 01/01/2018 - "Similarly, knockdown of β-catenin impaired intradermal melanoma cell invasion and PKF115-584 efficiently reduced liver metastasis in a chick chorioallantoic membrane model. "
5.	Colonic Neoplasms (Colon Cancer) 01/01/2012 - "We show here that the β-catenin inhibitors PKF115-584 and pyrvinium pamoate block β-catenin-dependent transcriptional activity and synergize with the KRAS inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS, salirasib) in colon cancer cells driven by Wnt and KRAS oncogenic signals, but not in cells carrying BRAF mutations. "

Related Drugs and Biologics

1.	TCF Transcription Factors
2.	beta Catenin
3.	CGP049090
4.	Catenins
5.	farnesylthiosalicylic acid
6.	pyrvinium (Vankin)