cytosporone B

11/01/2022 - "Activating NR4A1 with Csn-B, in the context of established inflammation, reduced ileal smooth muscle thickening in SAMP1/YitFc mice. "
03/01/2022 - "The results showed that Csn-B prolonged murine cardiac allograft survival and reduced inflammation in allografts. "
01/01/2020 - "Reactivation of NR4A1 by its agonist cytosporone B could inhibit IL-1β induced chondrocyte inflammation and expression of COX-2, iNOS, MMP3, MMP9, and MMP13. "
12/01/2016 - "Adoptive transfer of Ly6Clow monocytes in arthritic NR4A1-/- mice treated with Csn-B reduces joint inflammation, supporting the regulatory role of Ly6Clow subset on disease development. "
01/01/2020 - "NR4A1 agonist cytosporone B could reactivate and restore the inhibitory regulatory ability of NR4A1, prevent excessive inflammation, and ameliorates osteoarthritis."

01/01/2020 - "In rat OA model, intra-articular injection of cytosporone B protected cartilage damage and ameliorated osteoarthritis. "
01/01/2020 - "NR4A1 agonist cytosporone B could reactivate and restore the inhibitory regulatory ability of NR4A1, prevent excessive inflammation, and ameliorates osteoarthritis."

12/31/2022 - "Notably, the NR4A1 agonist cytosporone B sensitizes GLS inhibitor resistance to cancer cell death. "
02/01/2013 - "Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability."
02/01/2011 - "Cytosporone B and related compounds that induce NR4A1-dependent apoptosis in cancer cells through both modulation of nuclear NR4A1 and nuclear export are discussed. "
02/01/2013 - "These studies indicate that Csn-B and 5-Me-Csn-B, having a phenolic hydroxyl at the 3-position of their aromatic rings, had similar activities in inhibiting cancer cell viability and in inducing apoptosis, whereas 3,5-(Me)2-Csn-B was unable to do so. "
09/01/2008 - "Moreover, Csn-B induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release. "

12/01/2018 - "NR4A1 is an endogenous inhibitor of fibrosis in the vocal folds and Csn-B, as an NR4A1 agonist, may evolve as an ideal, therapeutic candidate for this challenging condition. "
01/01/2023 - "Csn-B treatment aggravated UUO-induced renal interstitial fibrosis, and induced p38 MAPK phosphorylation. "
01/01/2021 - "Using the SAMP1/YitFc mouse, we tested whether two pharmacological agents known to enhance NR4A1 signaling, cytosporone B (Csn-B) or 6-mercaptopurine (6-MP), could reduce fibrosis. "

05/01/2012 - "The TR3 agonist cytosporone B was used to evaluate the role of TR3 in intestinal tumorigenesis. "